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3.269 Aktuelle Fachpublikationen von AACR Publications


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Highlights from Recent Cancer Literature

15.05.2017 | American Association for Cancer Research, Cancer Research, 2017

Gholamin and colleagues treated malignant pediatric brain tumor models with a humanized anti-CD47 antibody (Hu59-G4). In primary and metastatic high-risk medulloblastoma, Hu5F9-G4 inhibited growth in vivo , including CD15-positive putative medulloblastoma stem cells. Because children with group 3


Antibody-Drug Conȷugates Bearing Pyrrolobenzodiazepine or Tubulysin Payloads Are Immunomodulatory and Synergize with Multiple Immunotherapies

15.05.2017 | Jonathan Rios-Doria; Jay Harper; Raymond Rothstein; Leslie Wetzel; Jon Chesebrough; Allison Marrero; Cui Chen; Patri ..., Cancer Research, 2017

Immunogenic cell death (ICD) is the process by which certain cytotoxic drugs induce apoptosis of tumor cells in a manner that stimulates the immune system. In this study, we investigated whether antibody–drug conjugates (ADCS) conjugated with pyrrolobenzodiazepine dimer (PBD) or tubulysin ...


Correction: Metastatic Progression of Prostate Cancer Is Mediated by Autonomous Binding of Galectin-4-O-Glycan to Cancer Cells

15.05.2017 | American Association for Cancer Research, Cancer Research, 2017

In this article [(Cancer Res 2016;76:5756–67)][1], which appeared in the October 1, 2016, issue of Cancer Research ([1][2]), there are errors in Figs. 2A and 6E. The authors used one trimmed image/blot to fit the size of the others. In these two panels, they accidentally kept the “ruler image/


Anti-PD-L1 Efficacy Can Be Enhanced by Inhibition of Myeloid-Derived Suppressor Cells with a Selective Inhibitor of PI3K{delta}/{gamma}

15.05.2017 | Ruth J. Davis; Ellen C. Moore; Paul E. Clavijo; Jay Friedman; Harrison Cash; Zhong Chen; Chris Silvin; Carter Van Wa ..., Cancer Research, 2017

Checkpoint inhibitors are relatively inefficacious in head and neck cancers, despite an abundance of genetic alterations and a T-cell–inflamed phenotype. One significant barrier to efficacy may be the recruitment of myeloid-derived suppressor cells (MDSC) into the tumor microenvironment. Here we ...


Models in Translational Oncology: A Public Resource Database for Preclinical Cancer Research

15.05.2017 | Claudia Galuschka; Rumyana Proynova; Benjamin Roth; Hellmut G. Augustin; Karin Müller-Decker, Cancer Research, 2017

The devastating diseases of human cancer are mimicked in basic and translational cancer research by a steadily increasing number of tumor models, a situation requiring a platform with standardized reports to share model data. Models in Translational Oncology (MiTO) database was developed as a ...


IL33 Promotes Colon Cancer Cell Stemness via JNK Activation and Macrophage Recruitment

15.05.2017 | Min Fang; Yongkui Li; Kai Huang; Shanshan Qi; Jian Zhang; Witold Zgodzinski; Marek Majewski; Grzegorz Wallner; Stani ..., Cancer Research, 2017

The expression and biological role of IL33 in colon cancer is poorly understood. In this study, we show that IL33 is expressed by vascular endothelial cells and tumor cells in the human colon cancer microenvironment. Administration of human IL33 and overexpression of murine IL33 enhanced human ...


Locoregional Effects of Microbiota in a Preclinical Model of Colon Carcinogenesis

15.05.2017 | Sarah Tomkovich; Ye Yang; Kathryn Winglee; Josee Gauthier; Marcus Mühlbauer; Xiaolun Sun; Mansour Mohamadzadeh; Xiul ..., Cancer Research, 2017

Inflammation and microbiota are critical components of intestinal tumorigenesis. To dissect how the microbiota contributes to tumor distribution, we generated germ-free (GF) ApcMin/+ and ApcMin/+ ; Il10−/− mice and exposed them to specific-pathogen-free (SPF) or colorectal cancer-associated ...


Correction: Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma

15.05.2017 | American Association for Cancer Research, Cancer Research, 2017

In this article [(Cancer Res 2016;76:6964–74)][1], which was published in the December 1, 2016, issue of Cancer Research ([1][2]), the authors regret that the legend for Supplementary Fig. S3 incorrectly noted “[…]as in panels for Fig. 2B and C.” It should read, “[…]as in panels for Fig


A Model-Based Personalized Cancer Screening Strategy for Detecting Early-Stage Tumors Using Blood-Borne Biomarkers

15.05.2017 | Sharon Seiko Hori; Amelie M. Lutz; Ramasamy Paulmurugan; Sanjiv Sam Gambhir, Cancer Research, 2017

An effective cancer blood biomarker screening strategy must distinguish aggressive from nonaggressive tumors at an early, intervenable time. However, for blood-based strategies to be useful, the quantity of biomarker shed into the blood and its relationship to tumor growth or progression must be ...


HDAC Inhibitor Panobinostat Engages Host Innate Immune Defenses to Promote the Tumoricidal Effects of Trastuzumab in HER2+ Tumors

15.05.2017 | Mikolaj Medon; Eva Vidacs; Stephin J Vervoort; Jason Li; Misty R. Jenkins; Kelly M. Ramsbottom; Joseph A. Trapani; M ..., Cancer Research, 2017

Histone deacetylase inhibitors (HDACi) may engage host immunity as one basis for their antitumor effects. Herein, we demonstrate an application of this concept using the HDACi panobinostat to augment the antitumor efficacy of trastuzumab (anti-HER2) therapy, through both tumor cell autonomous and ...


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