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1.685 Aktuelle Fachpublikationen aus der Branche Diagnostik

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Autoantibodies to tumor-associated antigens as diagnostic biomarkers in hepatocellular carcinoma and other solid tumors

07.04.2010 | Jian-Ying Zhang; Eng M Tan, Expert Review of Molecular Diagnostics, 2010

Liver cancer, especially hepatocellular carcinoma (HCC), is one of the most common tumors worldwide. The majority of people with HCC will die within 1 year of its detection. The high case–fatality rate can, in part, be attributed to a lack of diagnostic methods that enable the early detection of ...

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Evolving molecular diagnostics for familial cardiomyopathies: at the heart of it all

07.04.2010 | Thomas E Callis; Brian C Jensen; Karen E Weck; Monte S Willis, Expert Review of Molecular Diagnostics, 2010

Cardiomyopathies are an important and heterogeneous group of common cardiac diseases. An increasing number of cardiomyopathies are now recognized to have familial forms, which result from single-gene mutations that render a Mendelian inheritance pattern, including hypertrophic cardiomyopathy, ...

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Utilization of cytokeratin-based biomarkers for pharmacodynamic studies

07.04.2010 | Stig Linder; Maria Hägg Olofsson; Richard Herrmann; Engin Ulukaya, Expert Review of Molecular Diagnostics, 2010

Cytokeratin (CK)18 is a useful serum biomarker for the determination of cell death of epithelial-derived tumors (carcinomas). ELISAs are available for caspase-cleaved CK18 (M30) released from apoptotic cells, or total CK18 (M65) released by cells undergoing cell death by any cause. These assays ...

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Engineered cystine-knot miniproteins for diagnostic applications

07.04.2010 | Harald Kolmar, Expert Review of Molecular Diagnostics, 2010

Owing to their extraordinary thermal and biological stability, cystine-knot miniproteins provide an attractive scaffold for the development of peptide-based diagnostics. One of the major advantages of this scaffold lies in the fact that the disulfide-constrained structural core can be ...

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Acknowledgements

07.04.2010 | Expert Review of Molecular Diagnostics, 2010

Expert Review of Molecular Diagnostics , April 2010, Vol. 10, No. 3, Pages 373-373.

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