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62.533 Aktuelle Fachpublikationen aus der Branche Biotechnologie

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Craniofacial genetics: Where have we been and where are we going?

21.06.2018 | Seth M. Weinberg; Robert Cornell; Elizabeth J. Leslie, PLoS Genetics, 2018

by Seth M. Weinberg, Robert Cornell, Elizabeth J. Leslie

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Opposing roles of microRNA Argonautes during Caenorhabditis elegans aging

21.06.2018 | Antti P. Aalto; Ian A. Nicastro; James P. Broughton; Laura B. Chipman; William P. Schreiner; Jerry S. Chen; Amy E. P ..., PLoS Genetics, 2018

by Antti P. Aalto, Ian A. Nicastro, James P. Broughton, Laura B. Chipman, William P. Schreiner, Jerry S. Chen, Amy E. Pasquinelli Argonaute (AGO) proteins partner with microRNAs (miRNAs) to target specific genes for post-transcriptional regulation. During larval development in Caenorhabditis ...

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A component of the TOR (Target Of Rapamycin) nutrient-sensing pathway plays a role in circadian rhythmicity in Neurospora crassa

20.06.2018 | Lalanthi Ratnayake; Keyur K. Adhvaryu; Elizabeth Kafes; Kamyar Motavaze; Patricia Lakin-Thomas, PLoS Genetics, 2018

by Lalanthi Ratnayake, Keyur K. Adhvaryu, Elizabeth Kafes, Kamyar Motavaze, Patricia Lakin-Thomas The TOR (Target of Rapamycin) pathway is a highly-conserved signaling pathway in eukaryotes that regulates cellular growth and stress responses. The cellular response to amino acids or carbon ...

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Colorectal cancer mutational profiles correlate with defined microbial communities in the tumor microenvironment

20.06.2018 | Michael B. Burns; Emmanuel Montassier; Juan Abrahante; Sambhawa Priya; David E. Niccum; Alexander Khoruts; Timothy K ..., PLoS Genetics, 2018

by Michael B. Burns, Emmanuel Montassier, Juan Abrahante, Sambhawa Priya, David E. Niccum, Alexander Khoruts, Timothy K. Starr, Dan Knights, Ran Blekhman Variation in the gut microbiome has been linked to colorectal cancer (CRC), as well as to host genetic variation. However, we do not know ...

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FGF signaling deregulation is associated with early developmental skeletal defects in animal models for mucopolysaccharidosis type II (MPSII)

18.06.2018 | Bellesso S, Salvalaio M, Lualdi S, et al., Human Molecular Genetics, 2018

Human Molecular Genetics, 2018, 27(13), 2262–2275.

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Human demographic history has amplified the effects of background selection across the genome

18.06.2018 | Raul Torres; Zachary A. Szpiech; Ryan D. Hernandez, PLoS Genetics, 2018

by Raul Torres, Zachary A. Szpiech, Ryan D. Hernandez Natural populations often grow, shrink, and migrate over time. Such demographic processes can affect genome-wide levels of genetic diversity. Additionally, genetic variation in functional regions of the genome can be altered by natural ...

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Germline mutations and somatic inactivation of TRIM28 in Wilms tumour

18.06.2018 | Benjamin J. Halliday; Ryuji Fukuzawa; David M. Markie; Richard G. Grundy; Jackie L. Ludgate; Michael A. Black; Jane ..., PLoS Genetics, 2018

by Benjamin J. Halliday, Ryuji Fukuzawa, David M. Markie, Richard G. Grundy, Jackie L. Ludgate, Michael A. Black, Jane E. Skeen, Robert J. Weeks, Daniel R. Catchpoole, Aedan G. K. Roberts, Anthony E. Reeve, Ian M. Morison Wilms tumour is a childhood tumour that arises as a consequence of ...

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A conserved role for Syntaxin-1 in pre- and post-commissural midline axonal guidance in fly, chick, and mouse

18.06.2018 | Oriol Ros; Pablo José Barrecheguren; Tiziana Cotrufo; Martina Schaettin; Cristina Roselló-Busquets; Alba Vílchez-Aco ..., PLoS Genetics, 2018

by Oriol Ros, Pablo José Barrecheguren, Tiziana Cotrufo, Martina Schaettin, Cristina Roselló-Busquets, Alba Vílchez-Acosta, Marc Hernaiz-Llorens, Ramón Martínez-Marmol, Fausto Ulloa, Esther T. Stoeckli, Sofia J. Araújo, Eduardo Soriano Axonal growth and guidance rely on correct growth cone ...

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Unique patterns of trimethylation of histone H3 lysine 4 are prone to changes during aging in Caenorhabditis elegans somatic cells

18.06.2018 | Mintie Pu; Minghui Wang; Wenke Wang; Satheeja Santhi Velayudhan; Siu Sylvia Lee, PLoS Genetics, 2018

by Mintie Pu, Minghui Wang, Wenke Wang, Satheeja Santhi Velayudhan, Siu Sylvia Lee Tri-methylation on histone H3 lysine 4 (H3K4me3) is associated with active gene expression but its regulatory role in transcriptional activation is unclear. Here we used Caenorhabditis elegans to investigate the ...

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Yeast Cth2 protein represses the translation of ARE-containing mRNAs in response to iron deficiency

18.06.2018 | Lucía Ramos-Alonso; Antonia María Romero; Maria Àngel Soler; Ana Perea-García; Paula Alepuz; Sergi Puig; María Teres ..., PLoS Genetics, 2018

by Lucía Ramos-Alonso, Antonia María Romero, Maria Àngel Soler, Ana Perea-García, Paula Alepuz, Sergi Puig, María Teresa Martínez Pastor In response to iron deficiency, the budding yeast Saccharomyces cerevisiae undergoes a metabolic remodeling in order to optimize iron utilization. The tandem ...

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