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62.533 Aktuelle Fachpublikationen aus der Branche Biotechnologie


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Hydrogen peroxide is a neuronal alarmin that triggers specific RNAs, local translation of Annexin A2, and cytoskeletal remodeling in Schwann cells [ARTICLE]

01.07.2018 | Samuele Negro; Marco Stazi; Marta Marchioretto; Toma Tebaldi; Umberto Rodella; Elisa Duregotti; Volker Gerke; Alessa ..., RNA, 2018

Schwann cells are key players in neuro-regeneration: They sense "alarm" signals released by degenerating nerve terminals and differentiate toward a proregenerative phenotype, with phagocytosis of nerve debris and nerve guidance. At the murine neuromuscular junction, hydrogen peroxide (H2O2) is a ...


The importance of using public data to validate reported associations

29.06.2018 | Georgia Chenevix-Trench; Jonathan Beesley; Paul D. P. Pharoah; Andrew Berchuck, PLoS Genetics, 2018

by Georgia Chenevix-Trench, Jonathan Beesley, Paul D. P. Pharoah, Andrew Berchuck


Duplication of a Pks gene cluster and subsequent functional diversification facilitate environmental adaptation in Metarhizium species

29.06.2018 | Guohong Zeng; Peng Zhang; Qiangqiang Zhang; Hong Zhao; Zixin Li; Xing Zhang; Chengshu Wang; Wen-Bing Yin; Weiguo Fang, PLoS Genetics, 2018

by Guohong Zeng, Peng Zhang, Qiangqiang Zhang, Hong Zhao, Zixin Li, Xing Zhang, Chengshu Wang, Wen-Bing Yin, Weiguo Fang The ecological importance of the duplication and diversification of gene clusters that synthesize secondary metabolites in fungi remains poorly understood. Here, we ...


Within-patient mutation frequencies reveal fitness costs of CpG dinucleotides and drastic amino acid changes in HIV

28.06.2018 | Kristof Theys; Alison F. Feder; Maoz Gelbart; Marion Hartl; Adi Stern; Pleuni S. Pennings, PLoS Genetics, 2018

by Kristof Theys, Alison F. Feder, Maoz Gelbart, Marion Hartl, Adi Stern, Pleuni S. Pennings HIV has a high mutation rate, which contributes to its ability to evolve quickly. However, we know little about the fitness costs of individual HIV mutations in vivo, their distribution and the ...


Inositol polyphosphates regulate and predict yeast pseudohyphal growth phenotypes

25.06.2018 | Kaitlyn L. Norman; Christian A. Shively; Amberlene J. De La Rocha; Nebibe Mutlu; Sukanya Basu; Paul J. Cullen; Anuj ..., PLoS Genetics, 2018

by Kaitlyn L. Norman, Christian A. Shively, Amberlene J. De La Rocha, Nebibe Mutlu, Sukanya Basu, Paul J. Cullen, Anuj Kumar Pseudohyphal growth is a nutrient-regulated program in which budding yeast form multicellular filaments of elongated and connected cells. Filamentous growth is required ...


OFF-responses of interneurons optimize avoidance behaviors depending on stimulus strength via electrical synapses

25.06.2018 | Sayaka Hori; Shigekazu Oda; Yuji Suehiro; Yuichi Iino; Shohei Mitani, PLoS Genetics, 2018

by Sayaka Hori, Shigekazu Oda, Yuji Suehiro, Yuichi Iino, Shohei Mitani Optimization of the types and timing of avoidance behaviors depending on the intensity of a noxious stimulus is essential for survival; however, processing in the central nervous system and its developmental basis are ...


A survey on chimeric UreB229-561-HpaA protein targeting Helicobacter pylori: Computational and in vitro urease activity valuation

24.06.2018 | Author(s): Alireza Salimi Chirani, Mona Ghazi, Mehdi Goudarzi, Shahin Najar Peerayeh, Hoorieh Soleimanjahi ..., Computational Biology and Chemistry, 2018

Publication date: October 2018 Source:Computational Biology and Chemistry, Volume 76 Author(s): Alireza Salimi Chirani, Mona Ghazi, Mehdi Goudarzi, Shahin Najar Peerayeh, Hoorieh Soleimanjahi, Masoud Dadashi, Bahareh Hajikhani Helicobacter pylori (H. pylori) as ...


Tyrosinase inhibition by a rare neolignan: inhibition kinetics and mechanistic insights through in vitro and in silico studies

24.06.2018 | Author(s): Didem Şöhretoğlu, Suat Sari, Burak Barut, Arzu Özel, Computational Biology and Chemistry, 2018

Publication date: Available online 20 June 2018 Source:Computational Biology and Chemistry Author(s): Didem Şöhretoğlu, Suat Sari, Burak Barut, Arzu Özel Neolignans are a large group of polyphenols found in plants and exhibit a wide range of bioactivities including cytotoxicity, ...


CHMP1B is a target of USP8/UBPY regulated by ubiquitin during endocytosis

22.06.2018 | Xènia Crespo-Yàñez; Carmen Aguilar-Gurrieri; Anne-Claire Jacomin; Agnès Journet; Magda Mortier; Emmanuel Taillebourg ..., PLoS Genetics, 2018

by Xènia Crespo-Yàñez, Carmen Aguilar-Gurrieri, Anne-Claire Jacomin, Agnès Journet, Magda Mortier, Emmanuel Taillebourg, Emmanuelle Soleilhac, Winfried Weissenhorn, Marie-Odile Fauvarque Integration and down-regulation of cell growth and differentiation signals rely on plasma membrane receptors ...


The long and short of lifespan regulation by Argonautes

21.06.2018 | Kristen C. Brown; Taiowa A. Montgomery, PLoS Genetics, 2018

by Kristen C. Brown, Taiowa A. Montgomery


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