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Hydrogen peroxide is a neuronal alarmin that triggers specific RNAs, local translation of Annexin A2, and cytoskeletal remodeling in Schwann cells [ARTICLE]

01.07.2018 | Samuele Negro; Marco Stazi; Marta Marchioretto; Toma Tebaldi; Umberto Rodella; Elisa Duregotti; Volker Gerke; Alessa ..., RNA, 2018

Schwann cells are key players in neuro-regeneration: They sense "alarm" signals released by degenerating nerve terminals and differentiate toward a proregenerative phenotype, with phagocytosis of nerve debris and nerve guidance. At the murine neuromuscular junction, hydrogen peroxide (H2O2) is a ...

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The importance of using public data to validate reported associations

29.06.2018 | Georgia Chenevix-Trench; Jonathan Beesley; Paul D. P. Pharoah; Andrew Berchuck, PLoS Genetics, 2018

by Georgia Chenevix-Trench, Jonathan Beesley, Paul D. P. Pharoah, Andrew Berchuck

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Duplication of a Pks gene cluster and subsequent functional diversification facilitate environmental adaptation in Metarhizium species

29.06.2018 | Guohong Zeng; Peng Zhang; Qiangqiang Zhang; Hong Zhao; Zixin Li; Xing Zhang; Chengshu Wang; Wen-Bing Yin; Weiguo Fang, PLoS Genetics, 2018

by Guohong Zeng, Peng Zhang, Qiangqiang Zhang, Hong Zhao, Zixin Li, Xing Zhang, Chengshu Wang, Wen-Bing Yin, Weiguo Fang The ecological importance of the duplication and diversification of gene clusters that synthesize secondary metabolites in fungi remains poorly understood. Here, we ...

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Within-patient mutation frequencies reveal fitness costs of CpG dinucleotides and drastic amino acid changes in HIV

28.06.2018 | Kristof Theys; Alison F. Feder; Maoz Gelbart; Marion Hartl; Adi Stern; Pleuni S. Pennings, PLoS Genetics, 2018

by Kristof Theys, Alison F. Feder, Maoz Gelbart, Marion Hartl, Adi Stern, Pleuni S. Pennings HIV has a high mutation rate, which contributes to its ability to evolve quickly. However, we know little about the fitness costs of individual HIV mutations in vivo, their distribution and the ...

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Inositol polyphosphates regulate and predict yeast pseudohyphal growth phenotypes

25.06.2018 | Kaitlyn L. Norman; Christian A. Shively; Amberlene J. De La Rocha; Nebibe Mutlu; Sukanya Basu; Paul J. Cullen; Anuj ..., PLoS Genetics, 2018

by Kaitlyn L. Norman, Christian A. Shively, Amberlene J. De La Rocha, Nebibe Mutlu, Sukanya Basu, Paul J. Cullen, Anuj Kumar Pseudohyphal growth is a nutrient-regulated program in which budding yeast form multicellular filaments of elongated and connected cells. Filamentous growth is required ...

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OFF-responses of interneurons optimize avoidance behaviors depending on stimulus strength via electrical synapses

25.06.2018 | Sayaka Hori; Shigekazu Oda; Yuji Suehiro; Yuichi Iino; Shohei Mitani, PLoS Genetics, 2018

by Sayaka Hori, Shigekazu Oda, Yuji Suehiro, Yuichi Iino, Shohei Mitani Optimization of the types and timing of avoidance behaviors depending on the intensity of a noxious stimulus is essential for survival; however, processing in the central nervous system and its developmental basis are ...

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A survey on chimeric UreB229-561-HpaA protein targeting Helicobacter pylori: Computational and in vitro urease activity valuation

24.06.2018 | Author(s): Alireza Salimi Chirani, Mona Ghazi, Mehdi Goudarzi, Shahin Najar Peerayeh, Hoorieh Soleimanjahi ..., Computational Biology and Chemistry, 2018

Publication date: October 2018 Source:Computational Biology and Chemistry, Volume 76 Author(s): Alireza Salimi Chirani, Mona Ghazi, Mehdi Goudarzi, Shahin Najar Peerayeh, Hoorieh Soleimanjahi, Masoud Dadashi, Bahareh Hajikhani Helicobacter pylori (H. pylori) as ...

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Tyrosinase inhibition by a rare neolignan: inhibition kinetics and mechanistic insights through in vitro and in silico studies

24.06.2018 | Author(s): Didem Şöhretoğlu, Suat Sari, Burak Barut, Arzu Özel, Computational Biology and Chemistry, 2018

Publication date: Available online 20 June 2018 Source:Computational Biology and Chemistry Author(s): Didem Şöhretoğlu, Suat Sari, Burak Barut, Arzu Özel Neolignans are a large group of polyphenols found in plants and exhibit a wide range of bioactivities including cytotoxicity, ...

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CHMP1B is a target of USP8/UBPY regulated by ubiquitin during endocytosis

22.06.2018 | Xènia Crespo-Yàñez; Carmen Aguilar-Gurrieri; Anne-Claire Jacomin; Agnès Journet; Magda Mortier; Emmanuel Taillebourg ..., PLoS Genetics, 2018

by Xènia Crespo-Yàñez, Carmen Aguilar-Gurrieri, Anne-Claire Jacomin, Agnès Journet, Magda Mortier, Emmanuel Taillebourg, Emmanuelle Soleilhac, Winfried Weissenhorn, Marie-Odile Fauvarque Integration and down-regulation of cell growth and differentiation signals rely on plasma membrane receptors ...

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The long and short of lifespan regulation by Argonautes

21.06.2018 | Kristen C. Brown; Taiowa A. Montgomery, PLoS Genetics, 2018

by Kristen C. Brown, Taiowa A. Montgomery

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