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Small GTP-binding protein Ran is regulated by posttranslational lysine acetylation [Biochemistry]

Ran is a small GTP-binding protein of the Ras superfamily regulating fundamental cellular processes: nucleo-cytoplasmic transport, nuclear envelope formation and mitotic spindle assembly. An intracellular Ran•GTP/Ran•GDP gradient created by the distinct subcellular localization of its regulators RCC1 and RanGAP mediates many of its cellular effects. Recent proteomic screens identified five...

Autoren:   Susanne de Boor; Philipp Knyphausen; Nora Kuhlmann; Sarah Wroblowski; Julian Brenig; Lukas Scislowski; Linda Baldus; Hendrik Nolte; Marcus Krüger; Michael Lammers
Journal:   Proceedings of the National Academy of Sciences current issue
Band:   112
Ausgabe:   28
Jahrgang:   2015
Seiten:   E3679
DOI:   10.1073/pnas.1505995112
Erscheinungsdatum:   14.07.2015
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