No abstract is available for this article. mehr
Um alle Funktionen dieser Seite zu nutzen, aktivieren Sie bitte die Cookies in Ihrem Browser.
Mit einem my.bionity.com-Account haben Sie immer alles im Überblick - und können sich Ihre eigene Website und Ihren individuellen Newsletter konfigurieren.
New 5‐aryl‐10‐(4‐(4‐methoxyphenyl)thiazole‐2‐yl)‐9,10‐dihydropyrido[2,3‐d:5,6‐d′]dipyrimidinone‐2,4,6,8‐(1H,3H,5H,7H)‐tetraones 6a–d were synthesized through one‐pot four‐component reaction of aldehydes, barbituric acid, and thiazole using Zn2+@KSF under reflux condition. The key features of this reaction are: incorporating four heterocyclic rings, using a heterogeneous and efficient catalyst, high yield, and easy‐to‐setup reaction. The structure of the products was confirmed by FT‐IR, 1H NMR, and 13C NMR spectra. The antibacterial activities of compounds 6a–d were screened against Escherichia coli, Micrococcus luteus, Pseudomonas aeruginosa, and Staphylococcus aureus bacterial strains using the zone inhibition method. Also, the 2,2‐diphenyl‐2‐picrylhydrazyl (DPPH) radical scavenging activities of compounds 6a–d were evaluated. All compounds showed good antioxidant capacity in comparison to ascorbic acid. The IC50 values of the antioxidant activity were calculated. The proposed mechanism for antioxidant activity is discussed.
1,4‐Dihydropyridines were prepared from the reaction of barbituric acid, aldehydes, and thiazole in the presence of Zn2+@KSF. 10‐(4‐(4‐Methoxyphenyl)thiazole‐2‐yl)‐5‐(4‐nitrophenyl)‐9,10‐dihydropyrido[2,3‐d:5,6‐d′]dipyrimidone‐2,4,6,8‐(1H,3H,5H,7H)‐tetraone showed the best antibacterial and 10‐(4‐(4‐methoxyphenyl)thiazole‐2‐yl)‐5‐(2,4‐dichlorophenyl)‐9,10‐dihydropyrido[2,3‐d:5,6‐d′]dipyrimidone‐2,4,6,8‐(1H,3H,5H,7H)‐tetraone the highest antioxidant activity.
Abstract The single radial immunodiffusion assay has been the accepted method for determining the potency of inactivated influenza vaccines since 1978. The world‐wide adoption of this assay for vaccine standardisation was facilitated through collaborative studies that demonstrated a high ... mehr
Abstract Background Whether morbidity from the 1918‐19 influenza pandemic discriminated by socioeconomic status has remained a subject of debate for 100 years. In lack of data to study this issue recent literature have hypothesized that morbidity was “socially neutral”. Objectives ... mehr