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Viruses, Vol. 10, Pages 327: The Diversity of Bacterial Lifestyles Hampers Bacteriophage Tenacity

Viruses, Vol. 10, Pages 327: The Diversity of Bacterial Lifestyles Hampers Bacteriophage Tenacity

Viruses doi: 10.3390/v10060327

Authors: Marta Lourenço Luisa De Sordi Laurent Debarbieux

Phage therapy is based on a simple concept: the use of a virus (bacteriophage) that is capable of killing specific pathogenic bacteria to treat bacterial infections. Since the pioneering work of Félix d’Herelle, bacteriophages (phages) isolated in vitro have been shown to be of therapeutic value. Over decades of study, a large number of rather complex mechanisms that are used by phages to hijack bacterial resources and to produce their progeny have been deciphered. While these mechanisms have been identified and have been studied under optimal conditions in vitro, much less is known about the requirements for successful viral infections in relevant natural conditions. This is particularly true in the context of phage therapy. Here, we highlight the parameters affecting phage replication in both in vitro and in vivo environments, focusing, in particular, on the mammalian digestive tract. We propose avenues for increasing the knowledge-guided implementation of phages as therapeutic tools.

Autoren:   Lourenço, Marta ; De Sordi, Luisa ; Debarbieux, Laurent
Journal:   Viruses
Band:   10
Ausgabe:   6
Jahrgang:   2018
Seiten:   327
DOI:   10.3390/v10060327
Erscheinungsdatum:   15.06.2018
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