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Novel Kunitz-like Peptides Discovered in the Zoanthid Palythoa caribaeorum through Transcriptome Sequencing

Palythoa caribaeorum (class Anthozoa) is a zoanthid that together jellyfishes, hydra, and sea anemones, which are venomous and predatory, belongs to the Phyllum Cnidaria. The distinguished feature in these marine animals is the cnidocytes in the body tissues, responsible for toxin production and injection that are used majorly for prey capture and defense. With exception for other anthozoans, the toxin cocktails of zoanthids have been scarcely studied and are poorly known. Here, on the basis of the analysis of P. caribaeorum transcriptome, numerous predicted venom-featured polypeptides were identified including allergens, neurotoxins, membrane-active, and Kunitz-like peptides (PcKuz). The three predicted PcKuz isotoxins (1–3) were selected for functional studies. Through computational processing comprising structural phylogenetic analysis, molecular docking, and dynamics simulation, PcKuz3 was shown to be a potential voltage gated potassium-channel inhibitor. PcKuz3 fitted well as new functional Kunitz-ty...

Autoren:   Qiwen Liao; Shengnan Li; Shirley Weng In Siu; Binrui Yang; Chen Huang; Judy Yuet-Wa Chan; Jean-Étienne R. L. Morlighem; Clarence Tsun Ting Wong; Gandhi Rádis-Baptista; Simon Ming-Yuen Lee
Journal:   Journal of Proteome Research
Jahrgang:   2018
DOI:   10.1021/acs.jproteome.7b00686
Erscheinungsdatum:   12.01.2018
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