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To determine how frequently and effectively products of conception can be obtained among women pursuing medical management of early pregnancy loss.Methods
This pilot study was conducted to assess products of conception recovery outcomes for participants opting for medical management compared to women opting for surgical aspiration A tissue‐collection kit was provided to women opting for medical management. Outcomes measures included successful collection of products of conception, quantity and integrity of DNA, and participant satisfaction with the process.Results
Tissue was collected from 19 of 22 participants in the medical management group (84%) and 39 participants (100%) in the surgical management group (p = 0.02). DNA yield and integrity were similar among both groups (p = 0.03 and p = 0.003, respectively). Participants in the medical group reported a high comfort level with the kit and the process of tissue collection.Conclusions
Medical management of a missed abortion followed by patient controlled collection of products of conception for subsequent cytogenetic analysis is well‐tolerated and highly effective. This methodology may reduce the need for surgical management, empower women to have more agency in their medical decisions, and increase access to genetic testing.
Abstract The single radial immunodiffusion assay has been the accepted method for determining the potency of inactivated influenza vaccines since 1978. The world‐wide adoption of this assay for vaccine standardisation was facilitated through collaborative studies that demonstrated a high ... mehr
Abstract Background Whether morbidity from the 1918‐19 influenza pandemic discriminated by socioeconomic status has remained a subject of debate for 100 years. In lack of data to study this issue recent literature have hypothesized that morbidity was “socially neutral”. Objectives ... mehr
Ein höherer Kaffeekonsum steht in Zusammenhang mit einem geringeren Risiko für Gebärmutterkrebs, einer Krebsart, die in der Gebärmutterschleimhaut entsteht, so das Ergebnis einer Analyse einschlägiger, bisher veröffentlichter Studien. Außerdem bietet koffeinhaltiger Kaffee möglicherweise ei ... mehr