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Smad7 enables STAT3 activation and promotes pluripotency independent of TGF-{beta} signaling [Cell Biology]

Smad7 is a negative feedback product of TGF-β superfamily signaling and fine tunes a plethora of pleiotropic responses induced by TGF-β ligands. However, its noncanonical functions independent of TGF-β signaling remain to be elucidated. Here, we show that Smad7 activates signal transducers and activators of transcription 3 (STAT3) signaling in...

Autoren:   Yi Yu; Shuchen Gu; Wenjian Li; Chuang Sun; Fenfang Chen; Mu Xiao; Lei Wang; Dewei Xu; Ye Li; Chen Ding; Zongping Xia; Yi Li; Sheng Ye; Pinglong Xu; Bin Zhao; Jun Qin; Ye-Guang Chen; Xia Lin; Xin-Hua Feng
Journal:   Proceedings of the National Academy of Sciences current issue
Band:   114
Ausgabe:   38
Jahrgang:   2017
Seiten:   10113
DOI:   10.1073/pnas.1705755114
Erscheinungsdatum:   19.09.2017
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