No abstract is available for this article. mehr
Um alle Funktionen dieser Seite zu nutzen, aktivieren Sie bitte die Cookies in Ihrem Browser.
Mit einem my.bionity.com-Account haben Sie immer alles im Überblick - und können sich Ihre eigene Website und Ihren individuellen Newsletter konfigurieren.
To focus on fetuses diagnosed with severe hydronephrosis and correlate pre‐natal sonographic characteristics with post‐natal outcome.Methods
Cases presenting prenatally with severe hydronephrosis (APRPD) >15 mm) were collected retrospectively over a period of 11 years and divided into two groups: (1) isolated hydronephrosis and (2) those associated with congenital anomalies of the kidney and urinary tract (CAKUT).Results
83 fetuses comprised the study group: 35 fetuses had isolated severe hydronephrosis and 48 had associated CAKUT. The mean APRPD was 22.6±8.5mm (range 15.0‐66.0 mm).
The CAKUT group was associated with a significantly increased incidence of postnatal need for surgery (17.6% vs. 44.2%. p=0.014), dysplastic kidney (0%vs.14%. P=0.023), and total abnormal outcome (52.9% vs. 86%. p=0.001) in comparison to isolated severe prenatal hydronephrosis.Conclusions
Severe fetal hydronephrosis has a wide postnatal clinical spectrum which is mainly influenced by the presence of associated sonographic CAKUT findings. This clinical data has biological relevance: a genetic or environmental defect that influences multiple renal developmental processes leads to hydronephrosis but also to concomitant malformations (CAKUT) and critically influences renal prognosis. A more selective abnormal developmental process that results in isolated enlarged pelvis even to a severe extent has less influence on renal prognosis.
Abstract The single radial immunodiffusion assay has been the accepted method for determining the potency of inactivated influenza vaccines since 1978. The world‐wide adoption of this assay for vaccine standardisation was facilitated through collaborative studies that demonstrated a high ... mehr
Abstract Background Whether morbidity from the 1918‐19 influenza pandemic discriminated by socioeconomic status has remained a subject of debate for 100 years. In lack of data to study this issue recent literature have hypothesized that morbidity was “socially neutral”. Objectives ... mehr