No abstract is available for this article. mehr
Um alle Funktionen dieser Seite zu nutzen, aktivieren Sie bitte die Cookies in Ihrem Browser.
Mit einem my.bionity.com-Account haben Sie immer alles im Überblick - und können sich Ihre eigene Website und Ihren individuellen Newsletter konfigurieren.
A series of new hybrid benzimidazole containing pyridazinones derivatives were designed and synthesized in accordance with the pharmacophoric requirements essential for the anticonvulsant activity. The synthesized compounds were evaluated for anticonvulsant activity on mice by the gold standard maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ)‐induced seizure models. Among the compounds tested, SS‐4F showed significant anticonvulsant activity in both the screens with ED50 values of 25.10 and 85.33 mg/kg in the MES and scPTZ screens, respectively. Compound SS‐4F emerged as safer and effective anticonvulsant due to its several‐fold higher protective indices. Further, the gamma‐aminobutyric acid (GABA) estimation result showed a marked increase in the GABA level (1.7‐fold) as compared to the control, which was further confirmed by good binding properties with the GABAA receptor.
A series of new hybrid benzimidazole containing pyridazinones derivatives were designed and synthesized, and evaluated for anticonvulsant activity on mice based on the standard MES and scPTZ‐induced seizure models. Compound SS‐4F showed significant anticonvulsant activity with ED50 values of 25.10 and 85.33 mg/kg in the MES and scPTZ screen, respectively. It also had the highest protective indices.
Abstract The single radial immunodiffusion assay has been the accepted method for determining the potency of inactivated influenza vaccines since 1978. The world‐wide adoption of this assay for vaccine standardisation was facilitated through collaborative studies that demonstrated a high ... mehr
Abstract Background Whether morbidity from the 1918‐19 influenza pandemic discriminated by socioeconomic status has remained a subject of debate for 100 years. In lack of data to study this issue recent literature have hypothesized that morbidity was “socially neutral”. Objectives ... mehr