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MSn analysis with high mass accuracy with the LC detector LCMS-IT-TOF: Discover the unknown
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Coupling atmospheric pressure ionization with Ion-Trap (IT) and Time-of-Flight (TOF) technologies, the LCMS-IT-TOF delivers high mass accuracy and high mass resolution independent of MS mode. Due to the MSn capability of the instrument very detailed structural information can be generated from unknown compounds. Furthermore, in combination with the high mass accuracy and a new developed software tool the prediction of chemical elemental composition of a compound can be made in an efficient way. Additional to the mass accuracy the isotopic pattern matching is taking into account for a proper prediction. The LCMS-IT-TOF has been designed to maximize sensitivity and selectivity by optimizing the ion transport to the TOF analyzer and redefining the capability of the quadrupole ion trap. The ion trap is used to focus ions before ejection into the TOF as well as supporting MSn analysis with effective precursor ion selection capabilities.
Combining new, innovative technologies with one of the fastest polarity switching speeds available, the LCMS-IT-TOF expands the power of mass spectrometry scanning to deliver unparalleled performance for the most demanding analytical needs.
For example:
- Elucidate structures of new molecules
- Identify impurities and contaminants
- Analyze metabolites and biomarkers to evaluate biological pathways
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Thanks to the new Profiler software the analysis of Biomarker can be done in a fast and efficient way. The identification of Metabolites can be drastically accelerated by the use of the new MetID software package.
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Additional information
Shimadzu Deutschland GmbH Duisburg, Germany
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