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| Article 1 to 10 out of 13 concerning The Rockefeller University
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Metabolite common among cancers
(10 Feb 2010)
A study published in the Journal of Experimental Medicine (reports that several distinct mutations found in a subset of patients with acute myelogenous leukemia (AML) result in excess production of the same metabolite. The enzyme isocitrate ...
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Sanofi-aventis enters into an Exclusive Global Licensing Agreement with The Rockefeller University
(07 Dec 2009)
Development of a monoclonal antibody for the treatment of Alzheimer’s disease
Sanofi-aventis announced an exclusive global licensing agreement with The Rockefeller University concerning a novel monoclonal antibody, targeting certain specific forms of the Amyloid Beta parenchymal plaque for the treatment of Alzheimer’s ...
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Research shows power of FRET-based approach for distinguishing among distinct states of proteins
(02 Dec 2009)
In Journal of General Physiology, Moss et al. report a comprehensive investigation employing Förster resonance energy transfer (FRET) to study the {gamma}-amino acid (GABA) transporter GAT1, a member of the family that includes transporters for ...
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A natural approach for HIV vaccine
(17 Mar 2009)
Research suggests scientists should follow the body's lead to prevent HIV from taking root
For 25 years, researchers have tried and failed to develop an HIV vaccine, primarily by focusing on a small number of engineered "super antibodies" to fend off the virus before it takes hold. So far, these magic bullet antibodies have proved ...
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Turn back, wayward axon
(11 Mar 2009)
Study shows coreceptors work together as 'navigators' for a growing axon
To a growing axon, the protein RGMa is a "Wrong Way" sign, alerting it to head in another direction. As Hata et al. demonstrate in the Journal of Cell Biology, translating that signal into cellular action requires teamwork from two receptors.During ...
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Sarcospan, a little protein for a big problem
(05 Nov 2008)
The overlooked and undervalued protein, sarcospan, just got its moment in the spotlight. Peter et al. now show that adding it to muscle cells might ameliorate the most severe form of muscular dystrophy.In Duchenne muscular dystrophy (DMD), the ...
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Building the blood-brain barrier
(28 Oct 2008)
Construction of the brain's border fence is supervised by Wnt/b-catenin signaling, report Liebner et al. in The Journal of Cell Biology. Like many a modern nation, the brain requires tight border security to maintain levels of nutrients and keep out ...
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How neuronal activity leads to Alzheimer's protein cleavage
(23 Oct 2008)
Amyloid precursor protein (APP), whose cleavage product, amyloid-b (Ab), builds up into fibrous plaques in the brains of Alzheimer's disease patients, jumps from one specialized membrane microdomain to another to be cleaved, report Sakurai et ...
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Tick-borne encephalitis virus reveals its access code
(21 Oct 2008)
Fritz et al. have identified an amino acid switch that flaviviruses flip to gain access to cells.
Flaviviruses such as tick-borne encephalitis virus (TBEV), yellow fever, and dengue are dangerous human pathogens. These membrane-encircled viruses enter cells by being gobbled up into endosomes and fusing their membrane with that of the ...
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Stem cells stand up for themselves
(27 Aug 2008)
Adult stem cells are not pampered pushovers. O'Reilly et al. report that certain stem cells take charge of their surroundings, molding their environment to control their division and differentiation. Some stem cells are cosseted like newborns. ...
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