U3 Pharma achieves preclinical proof of concept for U3-1287 (AMG 888)(04/15/2008) HER3 antibody a promising novel first-in-class HER family inhibitor U3 Pharma announced that preclinical proof-of-concept has been established for its lead product U3-1287 (AMG 888), the first fully human anti-HER3 monoclonal antibody (mAb). In vitro and in vivo studies of U3-1287 (AMG 888), which is being developed ...