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Bionas and PRIMACYT to cooperate on cell-based assay for prediction of hepatotoxic effects of drugs and chemicals

22 Sep 2006 - Bionas and PRIMACYT have entered into a cooperation aimed at the development of a cell-based assay using primary human hepatocytes for prediction of hepatotoxic effects in response to test compounds.
 
Primary human hepatocytes, provided by PRIMACYT, are cultivated directly on collagen-coated BionasŪ metabolic chips. The chips are then placed into the Bionas analyzing system to evaluate the effect of test compounds. After a recovery period the hepatocytes can be re-used for further experiments.
 
Predicting liver toxicity is a major concern of the pharmaceutical industry and non-immortalized primary human hepatocytes can be used as biosensors for the analysis of drugs, food additives and chemicals.