Triiodothyronine
| Triiodothyronine |
|
|
| IUPAC name |
(2S)-2-amino-3- [4-(4-hydroxy-3-iodo-phenoxy)- 3,5-diiodo-phenyl]propanoic acid |
| Other names |
triiodothyronine
T3
cytomel
3,3',5-triiodo-L-thyronine |
| Identifiers |
| CAS number |
6893-02-3 |
| SMILES |
N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)
c(I)c1)C(O)=O |
| Properties |
| Molecular formula |
C15H12I3NO4 |
| Molar mass |
650.9776 g mol−1 |
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references |
Triiodothyronine, C15H12I3NO4, also known as T3, is a thyroid hormone.
This thyroid hormone is similar to thyroxine but with one fewer iodine atom per molecule. In addition, T3 exhibits greater activity and is produced in smaller quantity.
It is the most powerful thyroid hormone, and affects almost every process in the body, including body temperature, growth, and heart rate.
Reactions
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Endocrine system: hormones/endocrine glands (Peptide hormones, Steroid hormones) |
| Hypothalamic-pituitary |
Hypothalamus: TRH, CRH , GnRH, GHRH, somatostatin, dopamine - Posterior pituitary: vasopressin, oxytocin - Anterior pituitary: α (FSH, LH, TSH), GH, prolactin, POMC (ACTH, MSH, endorphins, lipotropin) |
| Adrenal axis |
Adrenal medulla: epinephrine, norepinephrine - Adrenal cortex: aldosterone, cortisol, DHEA |
| Thyroid axis |
Thyroid: thyroid hormone (T3 and T4) - calcitonin - Parathyroid: PTH |
| Gonadal axis |
Testis: testosterone, AMH, inhibin - Ovary: estradiol, progesterone, inhibin/activin, relaxin (pregnancy) |
| Other end. glands |
Pancreas: glucagon, insulin, somatostatin - Pineal gland: melatonin |
| Non-end. glands |
Placenta: hCG, HPL, estrogen, progesterone - Kidney: renin, EPO, calcitriol, prostaglandin - Heart atrium: ANP - Stomach: gastrin, ghrelin - Duodenum: CCK, GIP, secretin, motilin, VIP - Ileum: enteroglucagon - Adipose tissue: leptin, adiponectin, resistin - Thymus: Thymosin - Thymopoietin - Skeleton: Osteocalcin - Liver/other: Insulin-like growth factor (IGF-1, IGF-2) |
| Target-derived |
NGF, BDNF, NT-3 |
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