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Thiamphenicol
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Thiamphenicol
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| Systematic (IUPAC) name |
| 2,2-dichloro-N-[(1R,2R)- 1,3-dihydroxy-1- (4-methylsulfonylphenyl) propan-2-yl] acetamide |
| Identifiers |
| CAS number |
15318-45-3 |
| ATC code |
J01BA02 |
| PubChem |
27200 |
| DrugBank |
? |
| Chemical data |
| Formula |
C12H15Cl2NO5S |
| Mol. mass |
356.223 g/mol |
| Pharmacokinetic data |
| Bioavailability |
? |
| Metabolism |
hepatic |
| Half life |
5.0 hours |
| Excretion |
renal |
| Therapeutic considerations |
| Pregnancy cat. |
?
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| Legal status |
none
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| Routes |
IV, IM, O |
Thiamphenicol is an antibiotic. It is the methyl-sulfonyl analogue of chloramphenicol and has a similar spectrum of activity, but is 2.5 to 5 times as potent. Like chloramphenicol, is insoluble in water but highly soluble in lipids. It is used in many countries as a veterinary antibiotic, but is available in China and Italy for use in humans. Its main advantage over chloramphenicol is that it has never been associated with aplastic anaemia.
Alternative names
- Dextrosulphenidol
- Thiophenicol
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Thiamphenicol". A list of authors is available in Wikipedia.
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