 |
|
|
|
 |
|
|
TLR 1
|
Toll-like receptor 1
|
|
| PDB rendering based on 1fyv. |
| Available structures: 1fyv |
| Identifiers |
| Symbol(s) |
TLR1; CD281; DKFZp547I0610; DKFZp564I0682; KIAA0012; MGC104956; MGC126311; MGC126312; TIL; rsc786 |
| External IDs |
OMIM: 601194 MGI: 1341295 Homologene: 20694 |
| Gene Ontology |
| Molecular Function: |
• transmembrane receptor activity
• protein binding
• triacylated lipoprotein binding
|
| Cellular Component: |
• plasma membrane
• integral to plasma membrane
• phagocytic vesicle
|
| Biological Process: |
• inflammatory response
• signal transduction
• activation of NF-kappaB-inducing kinase
• macrophage activation
• detection of triacylated bacterial lipoprotein
• positive regulation of tumor necrosis factor biosynthetic process
• innate immune response
• positive regulation of interleukin-6 biosynthetic process
|
|
| RNA expression pattern |
|
More reference expression data
|
| Orthologs |
|
Human |
Mouse |
| Entrez |
7096 |
21897 |
| Ensembl |
ENSG00000174125 |
ENSMUSG00000044827 |
| Uniprot |
Q15399 |
Q6A0E8 |
| Refseq |
XM_001129777 (mRNA)
XP_001129777 (protein) |
NM_030682 (mRNA)
NP_109607 (protein) |
| Location |
Chr 4: 38.47 - 38.48 Mb |
Chr 5: 65.2 - 65.21 Mb |
| Pubmed search |
[1] |
[2] |
TLR 1 is a member of the Toll-like receptor family of pattern recognition receptors of the innate immune system. TLR1 recognizes pathogen-associated molecular pattern with a specificity for gram-positive bacteria.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene.[1]
References
- ^ Entrez Gene: TLR1 toll-like receptor 1.
Further reading
- Lien E, Ingalls RR (2002). "Toll-like receptors.". Crit. Care Med. 30 (1 Suppl): S1-11. PMID 11782555.
|
Transmembrane receptors: immune receptors |
| Cytokine receptor |
Type I: interleukin (IL-2, IL-3) - CSF (Erythropoietin, GM-CSF, G-CSF) - Glycoprotein 130/Oncostatin M - Leukemia inhibitory factor - common subunits (Common gamma chain, CSF2RB)
Type II: interleukin (IL22RA2) - interferon (IFNAR, IFNGR)
Other: Chemokine - TGF-beta - Tumor necrosis factor |
| Pattern recognition/Toll-like |
TLR 1 - TLR 2 - TLR 3 - TLR 4 - TLR 5 - TLR 6 - TLR 7 - TLR 8 - TLR 9 - TLR 10 |
| Fc receptor |
ε (FcεRI, FcεRII) - γ (FcγRI, FcγRII, FcγRIII) - α/μ (FcαRI, Fcα/μR) - Neonatal |
| Lymphocyte homing receptor |
CD44 - L-selectin - VLA-4 - LFA-1 |
| other |
Antigen receptor (B-cell, T cell) - Complement - Formyl peptide - Immunophilins - Integrin - Killer-cell immunoglobulin-like - Scavenger |
|
| |
|
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "TLR_1". A list of authors is available in Wikipedia.
|
Additional information matching your search term
Additional information was found matching your search for TLR 1.
|
|
|
|
|
Top