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Swainsonine
| Swainsonine |
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| IUPAC name |
(1S,2R,8R,8aR)-1,2,3,5,6,7,8,8a-Octahydroindolizine-
1,2,8-triol
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| Other names |
Tridolgosir |
| Identifiers |
| CAS number |
72741-87-8 |
| PubChem |
51683 |
| SMILES |
C1C[C@H]([C@@H]2[C@@H]([C@@H](CN2C1)O)O)O |
| Properties |
| Molecular formula |
C8H15NO3 |
| Molar mass |
173.21 g mol-1 |
| Melting point |
143-144 °C
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| Solubility in water |
10 mg/1 mL |
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references |
Swainsonine is a potent inhibitor of Golgi alpha-mannosidase II, immunomodulator and potential anticancer agent. Disruption of Golgi alpha-mannosidase II with swainsonine induces hybrid-type glycans. These glycans have a Man5GlcNAc2 core with processing on the 3-arm that resembles so-called complex-type glycans.
The pharmacological properties of this product have not been fully investigated.
Handling Instructions
- Soluble in water (10 mg/1 ml) and ethanol
- Use caution when handling.
- This product must not be used in humans
- Store between 0-4 ˚C for up to 1 year
- Store or 20 ˚C for up to 3 months
- Disposal: A
References
- Swainsonine at Logan Natural Products
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Swainsonine". A list of authors is available in Wikipedia.
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