Soluble low density lipoprotein receptor-related protein
Soluble low density lipoprotein receptor-related protein (sLRP) is a biological substance naturally produced by the human body.[1][2] This protein has been found to bind to and neutralize anywhere from 70 to 90 percent of the amyloid-beta peptide that also naturally circulates in healthy human or mouse plasma.[3] Impairment of this function is strongly associated with, and may soon be shown definitively to be the principal cause of, Alzheimer's Disease.[4]
References
^ Quinn KA, Pye VJ. et al. (1999). "Characterization of the soluble form of the low density lipoprotein receptor-related protein (LRP)". Exp. Cell Res.251 (2): 433-441. PMID 10471328.
^ Quinn KA, Grimsley PG, et al. (1997). "Soluble low density lipoprotein receptor-related protein (LRP) circulates in human plasma". J. Biol. Chem.272 (38): 23946-23951. PMID 9295345.
^ Draining away brain's toxic protein to stop Alzheimer's. Retrieved on 2007-10-25.
^ Sagare A, Deane R. et al. (2007). "Clearance of amyloid-beta by circulating lipoprotein receptors.". Nat. Med.13 (9): 1029-1031. PMID 17694066.
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