Serotonergic means "related to the neurotransmitter serotonin". A synapse is serotonergic if it uses serotonin as its neurotransmitter. A substance is serotonergic if it is capable of producing, altering, or releasing serotonin.

A serotonergic, or serotonergic agent, is any chemical which functions to enhance the effects mediated by serotonin in the central nervous system, and they include the following classes of chemicals:

• Serotonin precursors (such as tryptophan and 5-HTP)
• Cofactors required in the body's production of serotonin
• Serotonergic enzymes
• Selective serotonin reuptake inhibitor - A common class of serotonergic antidepressants
• Noradrenergic and specific serotonergic antidepressant - Another class of serotonergic antidepressants
• serotonergic psychedelics - The serotonergic hallucinogenic drugs

See also

• Cholinergic
• Dopaminergic
• Nootropic