Life Science Encyclopedia

Secoisolariciresinol diglycoside (SDG) (C₃₂H₄₆O₁₆) is an anti-oxidant phytochemical present in flax, sunflower, sesame, and pumpkin seeds. It is a precursor of mammal lignans and a phytoestrogen.

Animal studies have shown SDG can prevent the development of atherosclerosis and diabetes, and has beneficial modifying effect on blood and cholesterol levels.

Secoisolariciresinol diglucoside can be isolated from de-fatted (hexane extraction) flaxseed by extraction of the lignan polymer precursor with a water/acetone mixture, followed by acetone removal and alkaline hydrolysis.^[1]