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STAT4
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signal transducer and activator of transcription 4
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| Identifiers |
| Symbol |
STAT4 |
| Entrez |
6775 |
| HUGO |
11365 |
| OMIM |
600558 |
| RefSeq |
NM_003151 |
| UniProt |
Q14765 |
| Other data |
| Locus |
Chr. 2 q32.2-32.3 |
STAT4 is a STAT protein.
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Transcription factors and intracellular receptors |
| (1) Basic domains |
| (1.1) Basic leucine zipper (bZIP) |
Activating transcription factor (1, 2, 3, 4, 5, 6) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3) • GABPA • MAF (B, F, G, K) • NRL • NRF1 • XBP1 |
| (1.2) Basic helix-loop-helix (bHLH) |
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BMAL (ARNTL, ARNTL2) • CLOCK • HIF (1A, 3A) • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • NEUROD1 • Twist • USF1 |
| (1.3) bHLH-ZIP |
Myc • MITF • SREBP (1, 2) |
| (1.6) Basic helix-span-helix (bHSH) |
AP-2 |
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(2) Zinc finger
DNA-binding domains |
| (2.1) Nuclear receptor (Cys4) |
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP) |
| (2.2) Other Cys4 |
GATA (1, 2, 3, 4, 5, 6) |
| (2.3) Cys2His2 |
General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH: 1, 2) • GLI-Krüppel family (1, 2, 3, YY1) • KLF (2, 4, 5, 6, 10, 11, 12, 13) • Sp1 • zinc finger (3, 35, 43, 146, 148, 165, 217, 268, 281, 350) • Zbtb7 (7A) • ZBT (16, 17, 33) |
| (2.4) Cys6 |
HIVEP1 |
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(3) Helix-turn-helix
domains |
| (3.1) Homeo domain |
ARX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C6, C8, C9, C13, D1, D3, D4, D9, D10, D11, D12, D13) • NANOG • NKX (2-1, 2-5, 3-1) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) |
| (3.2) Paired box |
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9) |
| (3.3) Fork head / winged helix |
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, L2, M1, N3, O3, O4, P1, P2, P3) |
| (3.4) Heat Shock Factors |
HSF1 |
| (3.5) Tryptophan clusters |
ELF (4, 5) • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB |
| (3.6) TEA domain |
transcriptional enhancer factor 1, 2 |
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(4) β-Scaffold factors with
minor groove contacts |
| (4.1) Rel homology region |
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (5, C1, C2, C3, C4) |
| (4.2) STAT |
STAT (1, 2, 3, 4, 5, 6) |
| (4.3) p53 |
p53 |
| (4.4) MADS box |
Mef2 (A, B, C, D) • SRF |
| (4.7) High mobility group |
HNF (1A, 1B) • LEF1 • SOX (3, 4, 6, 9, 10, 13, 18) • SRY • SSRP1 |
| (4.10) Cold-shock domain |
CSDA |
| (4.11) Runt |
CBF (RUNX1, RUNX2, RUNX3) |
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(0) Other
transcription factors |
| (0.2) HMGI(Y) |
HMGA (1, 2) |
| (0.3) Pocket domain |
Rb • RBL1 • RBL2 |
| (0.6) Miscellaneous |
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • Rho/Sigma • R-SMAD |
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "STAT4". A list of authors is available in Wikipedia.
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