Tandem pore domain potassium channel
Two-pore-domain potassium channels: This family of 15 members form what is known as "leak channels" which possess Goldman-Hodgkin-Katz (open) rectification.[1] These channels are regulated by several mechanisms including oxygen tension, pH, mechanical stretch, and G-proteins. Their name is derived from the fact that the α subunits consist of four transmembrane segments, each containing two pore loops. As such, they structurally correspond to two inward-rectifier α subunits and thus form dimers in the membrane.
Below is a list of the 15 known two-pore-domain human potassium channels:[1]
| Gene |
Channel |
| KCNK1 |
K2p01.1 |
| KCNK2 |
K2p02.1 |
| KCNK3 |
K2p03.1 |
| KCNK4 |
K2p04.1 |
| KCNK5 |
K2p05.1 |
| KCNK6 |
K2p06.1 |
| KCNK7 |
K2p07.1 |
| KCNK9 |
K2p09.1 |
| KCNK10 |
K2p10.1 |
| KCNK12 |
K2p12.1 |
| KCNK13 |
K2p13.1 |
| KCNK15 |
K2p15.1 |
| KCNK16 |
K2p16.1 |
| KCNK17 |
K2p17.1 |
| KCNK18 |
K2p18.1 |
See also
References
- ^ a b Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev 57 (4): 527-40. doi:10.1124/pr.57.4.12. PMID 16382106.
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Membrane transport protein: ion channels |
| Ca2+: Calcium channel |
Voltage-dependent calcium channel (L-type/Cavα(1.1, 1.2, 1.3, 1.4), N-type, P-type/Cavα(2.1), Q-type, R-type, T-type, β-subunits (β1, β2, β4), γ-subunits (γ2) • Inositol triphosphate receptor • Ryanodine receptor • Cation channels of sperm • Two-pore channel |
| Na+: Sodium channel |
Navα (1.1, 1.2, 1.4, 1.5, 1.7, 1.9) • Navβ (1, 3, 4) • Epithelial sodium channel |
| K+: Potassium channel |
Voltage-gated (Kvα (1.1, 1.2, 1.3, 1.4, 1.5, 2.1, 4.2, 4.3, 7.1, 7.2, 7.3, 7.4, 10.1, 11.1/hERG) • Kvβ (1, 2), Shaker gene, KCNE1) • Calcium-activated (BK channel, SK channel, SK3) • Inward-rectifier Kir (1.1, 2.1, 2.2, 2.3, 3.1, 3.2, 3.4, 4.1, 4.2, 6.1, 6.2)) • Tandem pore domain K2P (1, 2, 3, 4, 6, 9) |
| Cl-: Chloride channel |
Cystic fibrosis transmembrane conductance regulator |
| Porin |
Aquaporin (1, 2, 3, 4) • Voltage-dependent anion channel (1) |
| Cations: TRP |
TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (Mucolipin-1) • TRPP (1, 2)• TRPV (1, 2, 3, 4, 5, 6) |
| Other/general |
Voltage-gated ion channel • Ligand-gated ion channel • Cyclic nucleotide-gated ion channel (α1, α3, β3, H1, H2, H4) • Stretch-activated ion channel |
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