Plasmin
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Plasminogen
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| PDB rendering based on 1b2i. |
| Available structures: 1b2i, 1bml, 1bui, 1cea, 1ceb, 1ddj, 1hpj, 1hpk, 1i5k, 1ki0, 1krn, 1l4d, 1l4z, 1pk4, 1pkr, 1pmk, 1qrz, 1rjx, 2doh, 2doi, 2pk4, 5hpg |
| Identifiers |
| Symbol(s) |
PLG; DKFZp779M0222 |
| External IDs |
OMIM: 173350 MGI: 97620 Homologene: 55452 |
| Gene Ontology |
| Molecular Function: |
• plasmin activity
• calcium ion binding
• protein binding
• peptidase activity
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| Cellular Component: |
• extracellular space
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| Biological Process: |
• proteolysis
• apoptosis
• induction of apoptosis
• blood coagulation
• negative regulation of cell proliferation
• negative regulation of angiogenesis
• tissue regeneration
• fibrinolysis
• negative regulation of blood vessel endothelial cell migration
• myoblast differentiation
• muscle maintenance
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| RNA expression pattern |
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More reference expression data
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| Orthologs |
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Human |
Mouse |
| Entrez |
5340 |
18815 |
| Ensembl |
ENSG00000122194 |
ENSMUSG00000059481 |
| Uniprot |
P00747 |
Q3V1T9 |
| Refseq |
NM_000301 (mRNA)
NP_000292 (protein) |
NM_008877 (mRNA)
NP_032903 (protein) |
| Location |
Chr 6: 161.04 - 161.09 Mb |
Chr 17: 12.22 - 12.26 Mb |
| Pubmed search |
[1] |
[2] |
Plasmin is an important enzyme (EC 3.4.21.7) present in blood that degrades many blood plasma proteins, most notably fibrin clots. The degradation of fibrin is termed fibrinolysis.
Functions
It is a serine protease that is released as plasminogen into the circulation and activated by tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), thrombin, fibrin and factor XII (Hageman factor). It is inactived by alpha 2-antiplasmin, a serine protease inhibitor (serpin).
Apart from fibrinolysis, plasmin proteolyses proteins in various other systems: it activates collagenases, some mediators of the complement system and weakens the wall of the Graafian follicle (leading to ovulation). It cleaves fibrin, fibronectin, thrombospondin, laminin and von Willebrand factor.
Pathology
Deficiency in plasmin may lead to thrombosis, as clots are not degraded adequately.
Further reading
- Anglés-Cano E, Rojas G (2003). "Apolipoprotein(a): structure-function relationship at the lysine-binding site and plasminogen activator cleavage site.". Biol. Chem. 383 (1): 93-9. PMID 11928826.
- Ranson M, Andronicos NM (2004). "Plasminogen binding and cancer: promises and pitfalls.". Front. Biosci. 8: s294-304. PMID 12700073.
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Globulins: beta globulins |
| Angiostatin - Haemopexin - Beta-2 microglobulin - Factor H - Plasminogen - Properdin - Sex hormone binding globulin - Transferrin |
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