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Piceatannol
| Piceatannol[1] |
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| IUPAC name |
5-[(E)-2-(3,4-dihydroxyphenyl)vinyl]benzene-1,3-diol |
| Other names |
3,4,3',5'-tetrahydroxy-trans-stilbene |
| Identifiers |
| CAS number |
10083-24-6 |
| PubChem |
667639 |
| SMILES |
C1=CC(=C(C=C1C=CC2=CC(=CC(=C2)O)O)O)O |
| Properties |
| Molecular formula |
C14H12O4 |
| Molar mass |
244.24 |
| Appearance |
Light tan to yellow powder |
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references |
Piceatannol (3,4,3',5'-tetrahydroxy-trans-stilbene) is a phenolic stilbenoid. It is a metabolite of resveratrol found in red wine. LMP2A, a viral protein-tyrosine kinase implicated in leukemia, non-Hodgkin's lymphoma and other diseases associated with Epstein-Barr virus, were found to be blocked by picetannol in vitro.[2] Therefore there is research interest in piceatannol as an anti-cancer and anti-EBV drug.[3]
See also
References
- ^ Piceatannol at Sigma-Aldrich
- ^ Geahlen RL, McLaughlin JL (1989). "Piceatannol (3,4,3',5'-tetrahydroxy-trans-stilbene) is a naturally occurring protein-tyrosine kinase inhibitor". Biochem. Biophys. Res. Commun. 165 (1): 241–5. PMID 2590224.
- ^ Swanson-Mungerson M, Ikeda M, Lev L, Longnecker R, Portis T (2003). "Identification of latent membrane protein 2A (LMP2A) specific targets for treatment and eradication of Epstein-Barr virus (EBV)-associated diseases". J. Antimicrob. Chemother. 52 (2): 152–4. doi:10.1093/jac/dkg306. PMID 12837743.
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Piceatannol". A list of authors is available in Wikipedia.
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