It is approved as an appetite suppressant to help reduce weight in obese patients when used short-term and combined with exercise, diet, and behavioral modification. It is typically prescribed for individuals who are at increased medical risk because of their weight and works by helping to release certain chemicals in the brain that control appetite.
Ionamin® (Slow Release Resin, Australia, discontinued in the US)
Duromine® (Slow Release Resin, New Zealand)
Obephen®
Obermine®
Obestin-30®
Phentrol®
Phenterex®
Phentromin®
Pro-Fast SA
Redusa
Panbesy
Phentermine Trenker
Obenix
Oby-Trim
History
In 1959 phentermine first received approval from the FDA as an appetite suppressing drug. Phentermine hydrochloride then became available in the early 1970s. It was previously sold as Fastin® from King Pharmaceuticals for SmithKline Beecham, however in 1998 it was removed from the market. Medeva Pharmaceuticals sells the name brand of phentermine called Ionamin® and Gate Pharmaceuticals sells it as Adipex-P®. Phentermine is also currently sold as a generic. Since the drug was approved in 1959 there have been almost no clinical studies performed. The most recent study was in 1990 which combined phentermine with fenfluramine or dexfenfluramine and became known as Fen-Phen.
A study was published in 1992 that Fen-Phen was more effective than diet and exercise with few side effects. However, in 1997 after 24 cases of heart valve disease in Fen-Phen users, fenfluramine and dexfenfluramine were voluntarily taken off the market at the request of the FDA. Studies later proved that nearly 30% of people taking fenfluramine or dexfenfluramine had abnormal valve findings. The FDA did not ask manufacturers to remove phentermine from the market.
Phentermine is still available by itself in most countries, including the U.S. However, because it is similar to amphetamines, individuals may develop an addiction to it. Hence, it is classified as a controlled substance in many countries. Internationally, phentermine is a schedule IV drug under the Convention on Psychotropic Substances.[1] In the United States, it is classified as a Schedule IV controlled substance under the Controlled Substances Act.
Mechanism of action
Phentermine, like many other prescription drugs, works with neurotransmitters in the brain. It is a centrally-acting stimulant and is a constitutional isomer (not to be confused with stereoisomer) of methamphetamine. It stimulates neuron bundles to release a particular group of neurotransmitters known as catecholamines; these include dopamine, epinephrine (also known as adrenalin), and norepinephrine (noradrenaline). The anorectic activity seen with these compounds is thus likely due to their effect on the central nervous system, which is consistent with current knowledge about the central nervous system and feeding behavior. This is the same mechanism of action as other stimulant appetite suppressants such as diethylpropion and phendimetrazine. The neurotransmitters signal a fight-or-flight response in the body which, in turn, puts a halt to the hunger signal. As a result, it causes a loss in appetite because the brain does not receive the hunger message.
Dosing and administration
Generally, it is recommended by the Food and Drug Administration (FDA) that phentermine should be used short-term (usually interpreted as 'up to 12 weeks'), while following nonpharmacological approaches to weight loss such as healthy dieting and exercise. However, recommendations limiting its use for short-term treatment may be controversial. One reason given behind limiting its use to 12 weeks is drug tolerance, whereby phentermine loses its appetite-suppressing effects after the body adjusts to the drug. On the contrary, it has been shown that phentermine did not lose effectiveness in a 36-week trial.[2] Due to the risk of insomnia, it is generally recommended that the drug be taken either before breakfast or 1-2 hours after breakfast.
Contraindications and warnings
Patients with the following should not use Phentermine:
Are also taking dexfenfluramine, fenfluramine, furazolidone, guanadrel, guanethidine, or have taken a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) in the last 14 days
Have severe high blood pressure, an overactive thyroid, glaucoma, heart or blood vessel disease, or severe narrowing of the blood vessels
Are in an agitated state, or have a history of substance abuse
Some medical conditions may interact with Phentermine, patients with the following should consult with their doctor before using phentermine:
Are pregnant, planning to become pregnant, or are breast-feeding
Are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
Have allergies to medicines, foods, or other substances
Some medicines may interact with Phentermine, such as the following:
Dexfenfluramine, fenfluramine, furazolidone, or MAOIs (eg, phenelzine) because the risk of serious side effects, such as increasing headache, high blood pressure, slow heart rate, elevated temperature, or possibly fatal lung problems, may be increased
Serotonin specific reuptake inhibitors (eg, fluoxetine) because the risk of their side effects may be increased by Phentermine
Guanadrel or guanethidine because their effectiveness may be decreased by Phentermine
Side effects
Generally, phentermine appears to be relatively well tolerated.[3] It can produce side effects consistent with its catecholamine-releasing properties, e.g., tachycardia (increased heart rate) and elevated blood pressure, but the incidence and magnitude of these appear to be less than with the amphetamines. Because phentermine acts through sympathomimetic pathways, the drug may increase blood pressure and heart rate. It may also cause palpitations, restlessness, and insomnia. Additionally, phentermine has the potential to cause physical and psychological dependence.
More Common Symptoms
Insomnia
Increased blood pressure
Irritability
Nervousness
Sense of well-being
Less Common to Rare Symptoms
Blurred vision
Change in sexual desire
Clumsiness
Confusion
Diarrhea
Dizziness
Dry mouth
Headache
Irregular heartbeat
Nausea or vomiting
Psychosis
Skin rash or itching
Stomach pain
Tiredness
Unpleasant taste
Possible Overdose Symptoms
Confusion
Convulsions (seizures)
Dizziness
Fast Breathing
Fever
Hallucinations
Hostility with urge to attack
Irregular blood pressure
Irregular heartbeat
Lightheadedness or Fainting
Mental Depression, following a period of excitement
^ Nelson DL, Gehlert DR. (2006). Central nervous system biogenic amine targets for control of appetite and energy expenditure. (HTML). Endocrine. 2006 Feb;29(1):49-60. PubMed. Retrieved on 6 May, 2006.
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