Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references
Penitrem A (tremortin) is a fungal neurotoxin found on ryegrass. It is produced by certain species of Aspergillus, Claviceps, and Penicillium. It inhibits potassium channels in smooth muscles.[citation needed] The maxi-channels targeted have their highest density in the cerebellar Purkinje cells.
The ED50 for penitrem A is 10 nM.[citation needed] The ED50 is the effective dose for 50% of the population. Many toxic chemicals do not show ED-50s and act by irreversible covalent adduction.
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