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Paracaspase
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mucosa associated lymphoid tissue lymphoma translocation gene 1
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| Identifiers |
| Symbol |
MALT1 |
| Alt. Symbols |
MLT |
| Entrez |
10892 |
| HUGO |
6819 |
| OMIM |
604860 |
| RefSeq |
NM_173844 |
| UniProt |
Q9UDY8 |
| Other data |
| Locus |
Chr. 18 q21 |
Paracaspases (human: MALT1) are related to caspases present in animals and slime mold, in contrast to metacaspases which are present in plants, fungi and "protists".[1]
Paracaspases are more similar to caspases than metacaspases are, indicating that this group of (putative) proteases diverged from caspases from a common metacaspase ancestor. The phylogenetic distribution is a bit confusing, since slime mold diverged earlier than the animal/fungal split.
References
- ^ Uren A, O'Rourke K, Aravind L, Pisabarro M, Seshagiri S, Koonin E, Dixit V (2000). "Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma". Mol Cell 6 (4): 961-7. PMID 11090634.
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Hydrolase: proteases (EC 3.4) |
| Exopeptidase 3.4.11-19 |
Angiotensin-converting enzyme - Dipeptidase - Dipeptidyl peptidase-4 - DD-transpeptidase
Metalloexopeptidases: Aminopeptidase (Alanine, Cystinyl, Leucyl, Glutamyl) - Carboxypeptidase (A, B, C, E, Glutamate II) |
| Endopeptidase 3.4.21-24 |
Serine proteases - Cysteine protease - Aspartic acid protease - Metalloendopeptidases |
| Cathepsin 3.4.18,21,22,23 |
A - B - C - K - S |
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Paracaspase". A list of authors is available in Wikipedia.
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