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P57 (gene)
Template:DISPLAYTITLE:p57 (gene) p57 or p57KIP2 is a tumor suppressor human gene on chromosome 11 (11p15) and belongs to the cip/kip gene family. It encodes a cell cycle inhibitor that binds to G1 cyclin-CDK complexes. [1] Thus p57KIP2 causes arrest of the cell cycle in G1 phase. A mutation of this gene may lead to loss of control over the cell cycle leading to uncontrolled cellular proliferation. p57KIP2 has been associated with Beckwith-Wiedemann syndrome (BWS) which is characterized by increased risk of tumor formation in childhood. [2]
References
- ^ p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene. GENES & DEVELOPMENT 9:650-662, 1995. ISSN 0890-9369.
- ^ New p57KIP2 mutations in Beckwith-Wiedemann syndrome Human Genetics, Vol 100, Num 5-6 / Sept 1997.
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Cell cycle proteins |
| Cyclin |
A - B - D - E |
| Cyclin-dependent kinase |
2 - 4 - 6 - 9 - CDK-activating kinase |
| Cyclin-dependent kinase inhibitor protein |
p14arf/p16INK4a - p21 - p27 - p57 |
| Other |
Cdc2 - Cdc25 - Cdc42 - Cellular apoptosis susceptibility protein - E2F - Maturation promoting factor - Wee |
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "P57_(gene)". A list of authors is available in Wikipedia.
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