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Marburg multiple sclerosis
Marburg multiple sclerosis, also known as malignant, acute or fulminant multiple sclerosis, is considered one of the multiple sclerosis borderline diseases, which is a collection of diseases classified by some as MS variants and by others as different diseases. Other diseases in this group are Neuromyelitis optica (NMO), Balo concentric sclerosis and Schilder's disease.[1]
It took its name from Otto Marburg. It can be diagnosed in vivo with an MRI.[2]
It is usually lethal, but recently it has been found to be responsive to Mitoxantrone[3] and Alemtuzumab,[4] and it has also been responsive to autologous stem cells transplantation.[5]
See also
References
- ^ Fontaine B (2001). "Borderline forms of multiple sclerosis" (in French). Rev. Neurol. (Paris) 157 (8-9 Pt 2): 929-34. PMID 11787357.
- ^ In vivo MRI diagnosis
- ^ Responsiveness to Mitoxantrone
- ^ Alemtuzumab and craniotomy for severe acute demyelinating illness [1]
- ^ Kimiskidis VK, Sakellari I, Tsimourtou V, et al (2007). "Autologous stem-cell transplantation in malignant multiple sclerosis: a case with a favorable long-term outcome". doi:10.1177/1352458507082604. PMID 17942513.
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Nervous system pathology, primarily CNS (G00-G47, 320-349) |
Inflammatory diseases
of the CNS |
Meningitis (Arachnoiditis) - Encephalitis - Myelitis - Encephalomyelitis (Acute disseminated) - Tropical spastic paraparesis |
Systemic atrophies
primarily affecting the CNS |
Huntington's disease - Spinocerebellar ataxia (Friedreich's ataxia, Ataxia telangiectasia, Hereditary spastic paraplegia)
Spinal muscular atrophy: Werdnig-Hoffman disease - Kugelberg-Welander disease - Fazio Londe syndrome -
MND (Amyotrophic lateral sclerosis (ALS), Progressive muscular atrophy (PMA), Progressive bulbar, Pseudobulbar, PLS) |
Extrapyramidal and
movement disorders |
Parkinson's disease - Neuroleptic malignant syndrome - Postencephalitic parkinsonism - Pantothenate kinase-associated neurodegeneration - Progressive supranuclear palsy - Striatonigral degeneration - Dystonia (Spasmodic torticollis, Meige's syndrome, Blepharospasm) - Essential tremor - Myoclonus - Chorea (Choreoathetosis) - Restless legs syndrome - Stiff person syndrome |
Other degenerative /
demyelinating diseases |
Alzheimer's disease - Pick's disease - Alpers' disease - Dementia with Lewy bodies - Leigh's disease - Multiple sclerosis - Devic's disease - Central pontine myelinolysis - Transverse myelitis |
| Seizure/epilepsy |
Focal (Simple partial, Complex partial) - Generalised (Tonic-clonic, Absence, Atonic, Benign familial neonatal) - Lennox-Gastaut - West - Epilepsia partialis continua - Status epilepticus (Complex partial status epilepticus) |
| Headache |
Migraine (Familial hemiplegic) - Cluster - Vascular - Tension |
| Vascular |
Transient ischemic attack (Amaurosis fugax, Transient global amnesia) - Cerebrovascular disease (MCA, ACA, PCA, Foville's syndrome, Millard-Gubler syndrome, Lateral medullary syndrome, Weber's syndrome, Lacunar stroke) |
| Sleep disorders |
Insomnia - Hypersomnia - Sleep apnea (Ondine's curse) - Narcolepsy - Cataplexy - Kleine-Levin syndrome - Circadian rhythm sleep disorder - Delayed sleep phase syndrome - Advanced sleep phase syndrome |
| Other |
Hydrocephalus (Normal pressure) - Idiopathic intracranial hypertension - Encephalopathy - Brain herniation - Cerebral edema - Reye's syndrome - Syringomyelia - Syringobulbia - Spinal cord compression |
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Marburg_multiple_sclerosis". A list of authors is available in Wikipedia.
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