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Iron overload disorder
Name of Symptom/Sign:
Iron overload disorder
Classifications and external resources
| ICD-10 |
R79.0 |
| ICD-9 |
790.6 |
In medicine, iron overload disorders are diseases caused by the accumulation of iron in the body. Organs commonly affected are the liver, heart and endocrine glands.[1]
Causes
The causes can be distinguished between primary (generally genetic) and secondary (due to other conditions).[2]
Primary iron overload
| Description |
OMIM |
Mutation |
| Haemochromatosis type 1: "classical"-haemochromatosis |
235200 |
HFE |
| Haemochromatosis type 2A: juvenile haemochromatosis |
602390 |
hemojuvelin ("HJV", also known as HFE2) |
| Haemochromatosis type 2B: juvenile haemochromatosis |
606464 |
hepcidin antimicrobial peptide (HAMP) or HFE2B |
| Haemochromatosis type 3 |
604720 |
transferrin receptor-2 (TFR2 or HFE3) |
| Haemochromatosis type 4 |
604653 |
ferroportin (SLC11A3) |
| Neonatal haemochromatosis |
231100 |
(unknown) |
| Aceruloplasminaemia (rare disease) |
604290 |
ceruloplasmin |
| Congenital atransferrinaemia (rare disease) |
209300 |
transferrin |
Secondary iron overload
Miscellaneous
The part-genetic, part-environmental syndrome known as African iron overload in sub-Sahara Africa (Online 'Mendelian Inheritance in Man' (OMIM) 601195)
See also
References
- ^ Andrews NC (1999). "Disorders of iron metabolism". N. Engl. J. Med. 341 (26): 1986-95. PMID 10607817.
- ^ Pietrangelo A (2003). "Haemochromatosis". Gut 52 Suppl 2: ii23-30. PMID 12651879.
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Iron_overload_disorder". A list of authors is available in Wikipedia.
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