Life Science Encyclopedia

Immunoproteomics is a term used to describe the study of large sets of proteins (proteomics) involved in the immune response.

Examples of common applications of immunoproteomics include:

• the isolation and mass spectrometric identification of MHC (major histocompatibility complex) binding peptides
• purification and identification of protein antigens binding specific antibodies (or other affinity reagents), and
• comparative immunoproteomics to identify proteins and pathways modulated by a specific infectious organism, disease or toxin.

The term proteomics also usually implies that mass spectrometry is the ultimate technique used for protein identification.

Further reading

• Purcell, A. W.; J. J. Gorman (March 2004). "Immunoproteomics: Mass Spectrometry-based Methods to Study the Targets of the Immune Response". Molecular & Cellular Proteomics 3 (3): 193-208. PubMed. Retrieved on 2006-11-21.