Hippocalcin is a calcium-binding protein that belongs to neuronal calcium sensor (NCS) family of proteins. It expressed in mammalian brains especially in the hippocampus. It possesses a Ca²⁺/myristoyl switch.

It takes part in the following prosesses:

• Activation of PLD and PLD2 expression

• Inhibition of apoptosis

• MAP kinase signalling

• Involved in long term depression in hippocampal neuron

• Required for normal spatial learning

It interacts with following proteins:

• Neuronal apoptosis inhibitory protein (NAIP)

• Mixed lineage kinase 2 (MLK2)MLK2 is myosin light chain kinase 2

• The b2 adaptin of the AP2 complex

• Calcium-dependent activator protein for secretion (CAPS)