HLA-DR15: Encyclopedia with 57,945 entries from biotech, medicine & life sciences.

HLA-DR15


major histocompatibility complex, class II, DR15
Haplotypes groups	DRA01:DRB11501 - to - DRA01:DRB11505 DRA01:DRB11507
Structure (See HLA-DR)
Identifiers	alpha *0101
Symbol(s)	HLA-DRA
EBI-HLA	DRA*0101
Identifiers	beta 1 1501 to 1505 *1507
Symbol(s)	HLA-DRB1
EBI-HLA	DRB1*1501
EBI-HLA	DRB1*1502
EBI-HLA	DRB1*1503
EBI-HLA	DRB1*1504
EBI-HLA	DRB1*1505
EBI-HLA	DRB1*1507
Shared data
Locus	chr.6 6p21.31

HLA-DR15(DR15) is a HLA-DR serotype that recognizes the DRB1*1501 to *1505 and *1507 gene products. DR15 is found at high levels from Ireland to Central Asia. frequencies. DR16 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR16 antigens.

1 Serology
2 Alleles
3 Disease associations
4 Extended linkage
5 Genetic Linkage
6 References

Serology

DR15, DR2 and other serotype recognition of some DRB1*15 alleles^[1]
DRB1*	DR15	DR2	DR16	Sample
allele	%	%	%	size (N)
1501	76	23		6428
1502	77	16		676
1503	81	13		286
1504	>50			1
1505	>25			2
1507	>50			1

Serotypes are unknown the following alleles: DRB1*1506, *1508 to *1516, *1518 to *1522. DRB1*1517N is a null.

Alleles

Disease associations

DR15 is positively associated goodpasture syndrome^[2], early age onset multiple sclerosis^[3], pernicious anaemia,^[4] sarcoidosis,^[5] and a predisposition for postmenopausal osteoporosis.^[6]

DRB1*1501 is positively associated with Goodpasture syndrome^[7]^[8], juvenile rheumatoid arthritis^[9], allergic bronchopulmonary aspergillosis^[10], multiple sclerosis^[11], systemic lupus erythematosus^[12], cervical cancer (human papillomavirus infection)^[13], and Sjogren's syndrome associated with systemic lupus erythematosus.^[14]

DRB1*1502 is associated with systemic lupus erythematosus^[15], systemic sclerosis (SSc) & anti-topoisomerase antibodies.^[16]

DRB1*1503 is associated with Chaga's cardiomyopathy^[17], allergic bronchopulmonary aspergillosis^[18], multiple sclerosis^[11], cervical cancer (human papillomavirus infection).^[19]

Extended linkage

DRB1*15:DQA1*0102:DQB1*0602 haplotype us associated with cervical cancer risk in (human papillomavirus infection)^[19]

DRB1*1502:DQA1*????:DQB1*0501 haplotype is associated with systemic lupus erythematosus^[15]

Genetic Linkage

Serotypes	DRA	DRB1	DRB5
DR15 Haplotypes
DR15(2)-DR51	*0101	*1501	*0101
	*0101	*1502	*0101
	*0101	*1503	*0101
	*0101	*1504	*0101
	*0101	*1505	*0101
	*0101	*1507	*0101
	DQA1	DQB1	DRB1
DR15(2)-DQ6(6.2, 1)	*0102	*0602	*1501
DR15(2)-DQ6(6.1, 1)	*0103	*0601	*1502
	HLA-A	HLA-B	DRB1
A3-Cw7-B7-DR15(2)	*0301	*0702	*1501
A1-B51-DR15(2)	*0101	*5101	*1502

HLA-DR15 is genetically linked to HLA-DR51 and HLA-DQ6 (HLA-DQ1) serotypes.

References

^ derived from IMGT/HLA
^ Phelps R, Jones V, Turner A, Rees A (2000). "Properties of HLA class II molecules divergently associated with Goodpasture's disease.". Int Immunol 12 (8): 1135-43. PMID 10917888.
^ Masterman T, Ligers A, Olsson T, Andersson M, Olerup O, Hillert J (2000). "HLA-DR15 is associated with lower age at onset in multiple sclerosis.". Ann Neurol 48 (2): 211-9. PMID 10939572.
^ Ungar B, Mathews J, Tait B, Cowling D (1981). "HLA-DR patterns in pernicious anaemia.". Br Med J (Clin Res Ed) 282 (6266): 768-70. PMID 6783164.
^ Bilir M, Sipahi S, Yilmaz E, et al (2007). "Analysis of HLA antigens in Turkish sarcoidosis patients". South. Med. J. 100 (4): 356-9. PMID 17458393.
^ Douroudis K, Tarassi K, Athanassiades T, et al (2007). "HLA alleles as predisposal factors for postmenopausal osteoporosis in a Greek population". Tissue Antigens 69 (6): 592-6. doi:10.1111/j.1399-0039.2007.00833.x. PMID 17498269.
^ Robertson J, Wu J, Arends J, Glass W, Southwood S, Sette A, Lou Y (2005). "Characterization of the T-cell epitope that causes anti-GBM glomerulonephritis.". Kidney Int 68 (3): 1061-70. PMID 16105036.
^ Phelps R, Rees A (1999). "The HLA complex in Goodpasture's disease: a model for analyzing susceptibility to autoimmunity.". Kidney Int 56 (5): 1638-53. PMID 10571772.
^ Garavito G, Yunis E, Egea E, Ramirez L, Malagón C, Iglesias A, De La Cruz O, Uribe O, Navarro E, Martinez P, Jaraquemada D (2004). "HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos.". Hum Immunol 65 (4): 359-65. PMID 15120191.
^ Slavin R, Hutcheson P, Chauhan B, Bellone C. "An overview of allergic bronchopulmonary aspergillosis with some new insights.". Allergy Asthma Proc 25 (6): 395-9. PMID 15709450.
^ ^a ^b Quelvennec E, Bera O, Cabre P, Alizadeh M, Smadja D, Jugde F, Edan G, Semana G (2003). "Genetic and functional studies in multiple sclerosis patients from Martinique attest for a specific and direct role of the HLA-DR locus in the syndrome.". Tissue Antigens 61 (2): 166-71. PMID 12694585.
^ Takeuchi F, Nakano K, Nabeta H, Hong G, Kawasugi K, Mori M, Okudaira H, Kuwata S, Tanimoto K (2005). "Genetic contribution of the tumour necrosis factor (TNF) B + 252*2/2 genotype, but not the TNFa,b microsatellite alleles, to systemic lupus erythematosus in Japanese patients.". Int J Immunogenet 32 (3): 173-8. PMID 15932622.
^ Apple R, Erlich H, Klitz W, Manos M, Becker T, Wheeler C (1994). "HLA DR-DQ associations with cervical carcinoma show papillomavirus-type specificity.". Nat Genet 6 (2): 157-62. PMID 8162070.
^ Manoussakis M, Georgopoulou C, Zintzaras E, Spyropoulou M, Stavropoulou A, Skopouli F, Moutsopoulos H (2004). "Sjögren's syndrome associated with systemic lupus erythematosus: clinical and laboratory profiles and comparison with primary Sjögren's syndrome.". Arthritis Rheum 50 (3): 882-91. PMID 15022331.
^ ^a ^b Sirikong M, Tsuchiya N, Chandanayingyong D, Bejrachandra S, Suthipinittharm P, Luangtrakool K, Srinak D, Thongpradit R, Siriboonrit U, Tokunaga K (2002). "Association of HLA-DRB1*1502-DQB1*0501 haplotype with susceptibility to systemic lupus erythematosus in Thais.". Tissue Antigens 59 (2): 113-7. PMID 12028537.
^ Kuwana M, Kaburaki J, Arnett F, Howard R, Medsger T, Wright T (1999). "Influence of ethnic background on clinical and serologic features in patients with systemic sclerosis and anti-DNA topoisomerase I antibody.". Arthritis Rheum 42 (3): 465-74. PMID 10088769.
^ García Borrás S, Diez C, Cotorruelo C, Pellizon O, Biondi C, Beloscar J, Bottasso O, Racca A (2006). "HLA class II DRB1 polymorphism in Argentinians undergoing chronic Trypanosoma cruzi infection.". Ann Clin Biochem 43 (Pt 3): 214-6. PMID 16704757.
^ Slavin R, Hutcheson P, Chauhan B, Bellone C. "An overview of allergic bronchopulmonary aspergillosis with some new insights.". Allergy Asthma Proc 25 (6): 395-9. PMID 15709450.
^ ^a ^b Maciag P, Schlecht N, Souza P, Franco E, Villa L, Petzl-Erler M (2000). "Major histocompatibility complex class II polymorphisms and risk of cervical cancer and human papillomavirus infection in Brazilian women.". Cancer Epidemiol Biomarkers Prev 9 (11): 1183-91. PMID 11097225.

v • d • e HLA DR Serotypes
DR - DR1 - DR2 - DR3 - DR4 - DR5 - DR6 - DR7 - DR8 - DR9 - DR10 - DR11 - DR12 - DR13 - DR14 - DR15 - DR16 - DR17 - DR18 - DR51 - DR52 - DR53

Category: HLA-DR haplotypes

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