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Gallamine
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Gallamine
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| Systematic (IUPAC) name |
| N-[2-[2,3-bis (2-diethylaminoethoxy) phenoxy]ethyl]- N-ethyl-ethanamine |
| Identifiers |
| CAS number |
65-29-2 |
| ATC code |
M03AC02 |
| PubChem |
67425 |
| DrugBank |
APRD00712 |
| Chemical data |
| Formula |
C24H45N3O3
C30H60N3O3+3 · 3 I- (gallamine triethiodide) |
| Mol. mass |
423.633 g/mol
891.529 g/mol (triethiodide) |
| Pharmacokinetic data |
| Bioavailability |
? |
| Metabolism |
? |
| Half life |
? |
| Excretion |
? |
| Therapeutic considerations |
| Pregnancy cat. |
?
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| Legal status |
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| Routes |
? |
Gallamine (as gallamine triethiodide) is a non-depolarising muscle relaxant. It acts by combining with the cholinergic receptor sites in muscle and competitively blocking the transmitter action of acetylcholine. Gallamine has a parasympatholytic effect on the cardiac vagus nerve which causes tachycardia and occasionally hypertension. Very high doses cause histamine release.
Gallamine is commonly used to stabilize muscle contractions during surgical procedures.
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Muscle relaxants (M03) |
Peripherally acting
(primarily antinicotinic,
neuromuscular-blocking drugs) |
curare alkaloids (Alcuronium, Dimethyltubocurarine, Tubocurarine) - choline derivatives (Suxamethonium) - other quaternary ammonium compounds (Atracurium, Cisatracurium, Doxacurium chloride, Fazadinium bromide, Gallamine, Hexafluronium, Mivacurium chloride, Pancuronium, Pipecuronium bromide, Rocuronium bromide, Vecuronium) - other (Botulinum toxin) |
| Centrally acting |
carbamic acid esters (Phenprobamate, Carisoprodol, Methocarbamol, Styramate, Febarbamate), Baclofen, Chlormezanone, Chlorzoxazone, Cyclobenzaprine, Lorazepam, Mephenesin, Orphenadrine, Phenyramidol, Pridinol, Tetrazepam, Thiocolchicoside, Tizanidine, Tolperisone |
| Directly acting |
Dantrolene |
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Gallamine". A list of authors is available in Wikipedia.
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