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GDP-fucose protein O-fucosyltransferase 2
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protein O-fucosyltransferase 2
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| Identifiers |
| Symbol |
POFUT2 |
| Alt. Symbols |
C21orf80 |
| Entrez |
23275 |
| HUGO |
14683 |
| OMIM |
610249 |
| RefSeq |
NM_133634 |
| UniProt |
Q9Y2G5 |
| Other data |
| Locus |
Chr. 21 q22.3 |
GDP-fucose protein O-fucosyltransferase 2 (POFUT2) is an enzyme responsible for adding fucose sugars in O linkage to serine or threonine residues in Thrombospondin repeats. The protein is an inverting glycosyltransferase, which means that the enzyme uses GDP-β-L-fucose as a donor substrate and transfers the fucose in O linkage to the protein producing fucose-α-O-serine/threonine.
Almost all glycosyltransferases reside in the Golgi apparatus. However, POFUT2 as well as the related enzyme POFUT1 have recently been shown to reside in the endoplasmic reticulum.
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Transferases: glycosyltransferases (EC 2.4) |
2.4.1 - Hexosyltransferases:
glucosyltransferase |
Phosphorylase (Starch, Glycogen, Myo-) - Glycogen synthase - Debranching enzyme - Branching enzyme - 1,3-beta-glucan synthase - Ceramide glucosyltransferase |
2.4.1 - Hexosyltransferases:
other |
Galactosyltransferase (Lactose synthase, B-N-acetylglucosaminyl-glycopeptide b-1,4-galactosyltransferase) - Glucuronosyltransferase (UGT1A1, UGT2B7, Hyaluronan synthase) - Fucosyltransferase (POFUT1, POFUT2) |
2.4.2 - Pentosyltransferases:
ADP ribose |
Cholera toxin - Diphtheria toxin - Pertussis toxin - Poly ADP ribose polymerase |
2.4.2 - Pentosyltransferases:
other |
Purine nucleoside phosphorylase - Adenine phosphoribosyltransferase - Hypoxanthine-guanine phosphoribosyltransferase - Uracil phosphoribosyltransferase - Amidophosphoribosyltransferase |
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "GDP-fucose_protein_O-fucosyltransferase_2". A list of authors is available in Wikipedia.
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