G12/G13: Encyclopedia with 57,945 entries from biotech, medicine & life sciences.

G12/G13

guanine nucleotide binding protein (G protein) alpha 12
Identifiers
Symbol	GNA12
Entrez	2768
HUGO	4380
OMIM	604394
RefSeq	NM_007353
UniProt	Q03113
Other data
Locus	Chr. 7 p22.3

guanine nucleotide binding protein (G protein), alpha 13
Identifiers
Symbol	GNA13
Entrez	10672
HUGO	4381
OMIM	604406
RefSeq	NM_006572
UniProt	Q14344
Other data
Locus	Chr. 17 q24

G12/G13 subunits are alpha units of heterotrimeric G proteins which regulate cell process through the use of guanine nucleotide exchange factors.

They are not sensitive to pertussis toxin.^[1]

Genes

^ Harhammer R, Nürnberg B, Harteneck C, Leopoldt D, Exner T, Schultz G (1996). "Distinct biochemical properties of the native members of the G12 G-protein subfamily. Characterization of G alpha 12 purified from rat brain". Biochem. J. 319 ( Pt 1): 165-71. PMID 8870664.

Dhanasekaran N., Dermott J.M. (1996). "Signaling by the G12 class of G proteins.". 'Cell. Sibnal.' 8: 235-45. PMID: 8842523 [1].

Wang D, Tan YC, Kreitzer GE, Nakai Y, Shan D, Zheng Y, Huang XY. (2006). "G proteins G12 and G13 control the dynamic turnover of growth factor-induced dorsal ruffles.". ' J Biol Chem.' 281: 32660-7. PMID: 16943201 [2].

Shan D, Chen L, Wang D, Tan YC, Gu JL, Huang XY (2006). "The G protein G alpha(13) is required for growth factor-induced cell migration.". 'Dev. Cell.' 10: 707-18. PMID: 16740474 [3].

v • d • e Acid anhydride hydrolases: GTPases/G proteins (EC 3.6.5)
3.6.5.1: Heterotrimeric G protein	G_αs - G_αi - G_αq/11 - G_α12/13 - Transducin
3.6.5.2: Small GTPase	Ras - Rab (Rab27) - Arf (Arf6) - Ran - Rheb - Rho (RhoA, RhoB, CDC42, Rac1) - Rap
3.6.5.3: Elongation factor	Prokaryotic - Eukaryotic
3.6.5.5-6: Other	Dynamin (is a GTPase, is not a G protein) - Tubulin

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