Floxuridine
Floxuridine
Systematic (IUPAC) name
5-Fluoro-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-pyrimidine-2,4-dione
Identifiers
CAS number
50-91-9
ATC code ?
PubChem 5790
DrugBank
APRD00692
Chemical data
Formula
C 9 H 11 F N 2 O 5
Mol. mass
246.193 g/mol
Pharmacokinetic data
Bioavailability ?
Metabolism ?
Half life
?
Excretion
?
Therapeutic considerations
Pregnancy cat.
?
Legal status
Routes ?
Floxuridine is an oncology drug that belongs to the class known as antimetabolites . The drug is most often used in the treatment of colorectal cancer.
Pharmacology
Floxuridine, an analog of 5-fluorouracil, is a fluorinated pyrimidine .
Meachanism of action
Floxuridine works because it is broken down by the body into its active form, which is the same as a metabolite of 5-Fluorouracil.
History
Floxuridine first gained FDA approval in December 1970 under the brand name FUDR. The drug was initially marketed by Roche, which also did a lot of the initial work on 5-fluorouracil. The National Cancer Institute was an early developer of the drug. Roche sold its FUDR product line in 2001 to Faulding, which became Mayne Pharma.
Suppliers
In the US the drug is supplied by Mayne Pharma as well as APP and Bedford.
Chemotherapeutic agents/Antineoplastic agents (L01)
Alkylating and alkylating-like agents Nitrogen mustards: (Chlorambucil , Chlormethine, Cyclophosphamide , Ifosfamide, Melphalan). Nitrosoureas: (Carmustine, Fotemustine, Lomustine, Streptozocin ). Platinum (alkylating-like): (Carboplatin , Cisplatin , Oxaliplatin , BBR3464 ). Busulfan, Dacarbazine , Procarbazine, Temozolomide , ThioTEPA , Uramustine
Antimetabolites Folic acid: (Aminopterin , Methotrexate , Pemetrexed , Raltitrexed). Purine: (Cladribine, Clofarabine , Fludarabine , Mercaptopurine , Pentostatin, Thioguanine). Pyrimidine :Capecitabine , Cytarabine , Fluorouracil, Floxuridine , Gemcitabine )
Spindle poison/mitotic inhibitor
Taxane: (Docetaxel , Paclitaxel ). Vinca: (Vinblastine, Vincristine , Vindesine, Vinorelbine ).
Cytotoxic/antitumor antibiotics Anthracycline family :Doxorubicin , Epirubicin , Idarubicin, Mitoxantrone , Valrubicin) - streptomyces Actinomycin , Bleomycin , Mitomycin , Plicamycin) - Hydroxyurea
Topoisomerase inhibitors
Camptotheca: (Camptothecin , Topotecan, Irinotecan ), Podophyllum :Etoposide , Teniposide )
CI monoclonal antibodies Receptor tyrosine kinase Cetuximab , Panitumumab , Trastuzumab ) - CD20 (Rituximab , Tositumomab) - other (Alemtuzumab , Bevacizumab , Gemtuzumab)
Photosensitizers Aminolevulinic acid , Methyl aminolevulinate, Porfimer sodium, Verteporfin
Tyrosine kinase inhibitorsDasatinib , Erlotinib , Gefitinib , Imatinib , Lapatinib, Nilotinib, Sorafenib, Sunitinib
Other
retinoids Tretinoin ) - Altretamine, Amsacrine, Anagrelide , Arsenic trioxide , Asparaginase (Pegaspargase), Bexarotene, Bortezomib , Denileukin diftitox, Estramustine, Ixabepilone, Masoprocol, Mitotane
Top