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Felypressin
Felypressin is added to some local anaesthetics such as prilocaine in a concentration of 0.003 i.u./ml. Felypressin is a non-catecholamine vasoconstrictor that is chemically related to vasopressin, the posterior pituitary hormone. Felypressin is a V1 Agonist, and will thus have affects at all V1 receptors. It will, however, have its main physiological effects on vascular SMC's due to the form in which it is administered.
V1 receptors are found in various sites around the body. The major points include the CNS, Liver, Anterior Pituitary, Muscle (both vascular and non-vascular smooth muscle), and Platelets (CLAMP).
Another example of a V1 Agonist is Terlipressin - which is used in Oesophageal Varices.
References
- "Vasopressin analogues and treatments", Prof Buckingham, ICSM - adapted by JHPatel
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Felypressin". A list of authors is available in Wikipedia.
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