Life Science Encyclopedia

Ethcathinone (also called Ethylpropion, N-ethylcathinone and 2-ethylaminopropiophenone), is a stimulant drug. It is an active metabolite of diethylcathinone and has a stimulant effect on the CNS.

Pharmacology

Ethcathinone is a methylphenidate-like DA/NE reuptake inhibitor (Rothman 2005). Its mechanism of action is similar to other appetite suppressants such as sibutramine, phentermine and dextroamphetamine. Chemically, it is the N-ethyl homologue of cathinone and dimethylcathinone.

Side effects

Severe

• Insomnia
• Pulmonary hypertension
• Stroke
• Psychosis

Cardiovascular

• Tachycardia, hypertension, arrhythmia, chest pain

Ear, nose, and throat

• Xerostomia, metallic taste

Endocrine

• Changes in libido, gynecomastia, menstrual irregularities

Eye

• Blurred vision

Gastrointestinal

• Nausea/vomiting, constipation, abdominal cramps

Hematological

• Bone marrow depression, agranulocytosis, leukopenia

Neurological

• Tremor

Psychological

• Euphoria, agitation, nervousness, restlessness, dizziness, anxiety, headache, mental depression, seizures

Skin

• Rash, hives, alopecia, ecchymosis

Urogenital and reproductive

• Changes in libido, impotence

See also

• Cathinone
• Diethylcathinone
• Methcathinone
• Methylenedioxymethcathinone

References