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Diacylglycerol lipase
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diacylglycerol lipase, alpha
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| Identifiers |
| Symbol |
DAGLA |
| Alt. Symbols |
C11orf11 |
| Entrez |
747 |
| HUGO |
1165 |
| RefSeq |
NM_006133 |
| UniProt |
Q9Y4D2 |
| Other data |
| Locus |
Chr. 11 q12.3 |
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diacylglycerol lipase, beta
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| Identifiers |
| Symbol |
DAGLB |
| Entrez |
221955 |
| HUGO |
28923 |
| RefSeq |
NM_139179 |
| UniProt |
Q8NCG7 |
| Other data |
| Locus |
Chr. 7 p22.1 |
Diacylglycerol lipase, also known as DAG lipase, DAGL or DGL, is a key enzyme in the biosynthesis of the endocannabinoid 2-arachidonoylglycerol.[1] It catalyzes the hydrolysis of diacylglycerol releasing a free fatty acid and monoacylglycerol.
Two separate genes encoding DGL enzymes have been cloned, termed DGLα (DAGLA) and DGLβ (DAGLB), that share 33% sequence identity.
Inhibitors
The enzyme has been described to be inhibited selectively by two agents, RHC80267 and tetrahydrolipstatin.
References
- ^ Bisogno, T. et al. Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. J. Cell. Biol. 2003 (163)3:463. Article
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Hydrolase: esterases (EC 3.1) |
| 3.1.1: Carboxylic ester hydrolases |
Cholinesterase - Pectinesterase - 6-phosphogluconolactonase - PAF acetylhydrolase
Lipase (Gastric/Lingual, Pancreatic, Lysosomal, Hormone-sensitive, Endothelial, Hepatic, Lipoprotein, Monoacylglycerol, Diacylglycerol)
Phospholipase (A1, A2, B) |
| 3.1.2: Thioesterase |
Palmitoyl thioesterase - Ubiquitin carboxy-terminal hydrolase L1 |
| 3.1.3: Phosphatase |
Alkaline phosphatase - Acid phosphatase (Prostatic)/Tartrate resistant acid phosphatase/Purple acid phosphatases - Nucleotidase - Glucose 6-phosphatase - Fructose 1,6-bisphosphatase - Calcineurin - Phosphoprotein phosphatase (PP2A) - OCRL - Pyruvate dehydrogenase phosphatase - Fructose 2,6-bisphosphatase - Protein tyrosine phosphatase - PTEN |
| 3.1.4: Phosphodiesterase |
Autotaxin - Phospholipase (C, D) - Sphingomyelin phosphodiesterase - PDE1 - PDE2 - PDE3 - PDE5 |
| 3.1.6: Sulfatase |
Arylsulfatase B - Steroid sulfatase - Galactosamine-6 sulfatase - Arylsulfatase A - Iduronate-2-sulfatase - N-acetylglucosamine-6-sulfatase |
| other |
Nuclease |
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Diacylglycerol_lipase". A list of authors is available in Wikipedia.
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