Amorolfine
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Amorolfine
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| Systematic (IUPAC) name |
(2S,6R)-2,6-dimethyl-4-[2-methyl-3-[4-
(2-methylbutan-2-yl)phenyl]propyl]morpholine |
| Identifiers |
| CAS number |
60719-84-8 |
| ATC code |
D01AE16 |
| PubChem |
54260 |
| Chemical data |
| Formula |
C21H35N |
| Mol. mass |
317.509 g/mol |
| Pharmacokinetic data |
| Bioavailability |
? |
| Metabolism |
? |
| Half life |
? |
| Excretion |
? |
| Therapeutic considerations |
| Pregnancy cat. |
?
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| Legal status |
|
| Routes |
? |
Amorolfine (or amorolfin), is an antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes.
Marketed as Curanail, Loceryl, Amorolfine is commonly available in the form of a Nail Lacquer, containing 5% Amorolfine as the active ingredient. It is currently available over the counter in the UK, having recently been re-classified from prescription-only status.
Amorolfine exhibits a broad spectrum of action, meaning that it kills a wide variety of different fungi, and when used as directed can actually cure the infection for a majority of sufferers.
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Antifungals (D01 and J02) |
| Antibiotics |
Griseofulvin • polyene antimycotics (Natamycin, Nystatin) |
| Topical azoles |
imidazoles (Bifonazole, Clomidazole, Clotrimazole, Econazole, Fenticonazole, Ketoconazole, Isoconazole, Miconazole, Oxiconazole, Sertaconazole, Sulconazole, Tioconazole) • triazoles (Fluconazole) • benzimidazole (Thiabendazole) |
| Other topicals |
Ciclopirox • Ethylparaben • Flucytosine • Salicylic acid • Selenium sulfide • Tolnaftate • Undecylenic acid • allylamines (Amorolfine, Butenafine, Naftifine, Terbinafine) |
| For systemic use |
Griseofulvin • allylamine (Terbinafine) • polyene antimycotic (Amphotericin B) • triazoles (Itraconazole, Posaconazole, Voriconazole) • echinocandins (Anidulafungin, Caspofungin, Micafungin) |
| Other |
Tea tree oil • citronella oil • lemon grass • orange oil • patchouli • lemon myrtle |
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