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ACVR1C
| Activin receptor type 1C |
| Other names: |
ACTR-IC, Activin receptor-like kinase 7, ALK-7 |
| Genetic data |
| Gene code: |
HUGO code:ACVR1C |
| Protein Structure/Function |
| Protein type: |
Serine/Threonine receptor kinase |
| Domains: |
GS domain, TS domain, S/T domain |
| Other |
| Taxa expressing: |
Homo sapiens; homologs: many metazoan phyla |
| Cell types: |
ubiquitous |
| Subcellular localization: |
Plasma membrane |
| Enzymatic Data |
| Catalytic activity: |
ATP + (receptor-protein) = ADP + (receptor-protein) phosphate |
| Cofactor(s): |
Magnesium or manganese |
ACVR1C or ALK-7 transduces signals of Nodal. Nodal binds to ACVR2B and then forms a comlex with ACR1C. These go on to recruit the R-SMADs SMAD2 or SMAD3.[1]
References
- ^ Inman, GJ; Nicolas FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, Laping NJ, Hill CS. (Jul 2002). "SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7". Mol Pharmacol. 62 (1). Entrez PubMed 12065756. Retrieved on 2006-07-05.
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Cell signaling: TGF beta signaling pathway |
| TGF beta superfamily of ligands |
TGF beta family (TGF-β1, TGF-β2, TGF-β3)
Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15)
Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, Myostatin/GDF8, GDF9, GDF10, GDF11, GDF15)
Other (Activin A and B/Inhibin A and B, Anti-müllerian hormone, Nodal) |
| TGF beta receptors |
TGFBR1: Activin type 1 receptors (ACVR1, ACVR1B, ACVR1C) - ACVRL1 - BMPR1 (BMPR1A - BMPR1B)
TGFBR2: Activin type 2 receptors (ACVR2A, ACVR2B) - AMHR2 - BMPR2
TGFBR3: betaglycan |
| Transducers/SMAD |
R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) - I-SMAD (SMAD6, SMAD7) - SMAD4 |
| Ligand Inhibitors |
Cerberus - Chordin - DAN - Decorin - Follistatin - Gremlin - Lefty - LTBP1 - Noggin - THBS1 |
| Coreceptors |
BAMBI - Cripto |
| Other |
SARA |
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "ACVR1C". A list of authors is available in Wikipedia.
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