ACVR1B
| Activin receptor type 1B |
| Other names: |
ACTR-IB, Serine/threonine-protein kinase receptor R2, SKR2, Activin receptor-like kinase 4, ALK-4 |
| Genetic data |
| Gene code: |
HUGO code: ACVR1B |
| Protein Structure/Function |
| Protein type: |
Serine/Threonine receptor kinase |
| Domains: |
GS domain, TS domain, S/T domain |
| Other |
| Taxa expressing: |
Homo sapiens; homologs: many metazoan phyla |
| Cell types: |
ubiquitous |
| Subcellular localization: |
Plasma membrane |
| Enzymatic Data |
| Catalytic activity: |
ATP + (receptor-protein) = ADP + (receptor-protein) phosphate |
| Cofactor(s): |
Magnesium or manganese |
| Medical/Biotechnological data |
| Diseases: |
Pancreatic Carcinoma |
ACVR1B or ALK-4 acts as a transducer of Activin or activin like ligands (eg. Inhibin) signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. These go on to recruit the R-SMADs SMAD2 or SMAD3.[1] ACVR1B also transduces signals of nodal, GDF-1, and Vg1; however, unlike activin, they require other coreceptor molecules such as the protein Cripto[2].
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| Identifiers |
| Symbol |
ACVR1B |
| Alt. Symbols |
ACVRLK4 |
| Entrez |
91 |
| HUGO |
172 |
| OMIM |
601300 |
| RefSeq |
NM_020328 |
| UniProt |
P36896 |
| Other data |
| EC number |
2.7.11.30 |
| Locus |
Chr. 12 q13 |
References
- ^ Inman, GJ; Nicolas FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, Laping NJ, Hill CS. (Jul 2002). "SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7". Mol Pharmacol. 62 (1). Entrez PubMed 12065756. Retrieved on 2006-07-05.
- ^ Harrison, CA; Gray PC, Koerber SC, Fischer W, Vale W (Jun 2003). "Identification of a functional binding site for activin on the type I receptor ALK4". J Biol Chem. 278 (23). Entrez PubMed 12665502. Retrieved on 2006-07-05.
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Cell signaling: TGF beta signaling pathway |
| TGF beta superfamily of ligands |
TGF beta family (TGF-β1, TGF-β2, TGF-β3)
Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15)
Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, Myostatin/GDF8, GDF9, GDF10, GDF11, GDF15)
Other (Activin A and B/Inhibin A and B, Anti-müllerian hormone, Nodal) |
| TGF beta receptors |
TGFBR1: Activin type 1 receptors (ACVR1, ACVR1B, ACVR1C) - ACVRL1 - BMPR1 (BMPR1A - BMPR1B)
TGFBR2: Activin type 2 receptors (ACVR2A, ACVR2B) - AMHR2 - BMPR2
TGFBR3: betaglycan |
| Transducers/SMAD |
R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) - I-SMAD (SMAD6, SMAD7) - SMAD4 |
| Ligand Inhibitors |
Cerberus - Chordin - DAN - Decorin - Follistatin - Gremlin - Lefty - LTBP1 - Noggin - THBS1 |
| Coreceptors |
BAMBI - Cripto |
| Other |
SARA |
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