X-Ray Crystallography

News X-Ray Crystallography

• UCB and Proteros expand successful protein x-ray crystallography collaboration

  UCB and Proteros biostructures GmbH announced expansion of their ongoing structural biology collaboration to include additional therapeutic areas. Since 2007, Proteros has supported discovery programmes for UCB in the area of immunology, by solving complex unpublished protein structures to give UCB more

• Determination of the immunoproteasome crystal structure
  

  Like a shredder, the immunoproteasome cuts down proteins into peptides that are subsequently presented on the cellular surface. The immune system can distinguish between self and nonself peptides and selectively kills cells that due to a viral infection present non-self peptides at their surface. In more

• Heptares scientists report the first use of structure-based drug design to discover GPCR-targeted drug candidate

  Heptares Therapeutics provided an update on recent scientific publications that highlight its unique ability to generate valuable information on GPCR structures and ligand binding. In the first of two new papers published in Journal of Medicinal Chemistry, Heptares scientists describe how completely more

Publications X-Ray Crystallography

• Neocosmospora sp.-Derived Resorcylic Acid Lactones with in Vitro Binding Affinity for Human Opioid and Cannabinoid Receptors

  Bioassay-guided fractionation of a fungus Neocosmospora sp. (UM-031509) resulted in the isolation of three new resorcylic acid lactones, neocosmosin A (2), neocosmosin B (3), and neocosmosin C (4). Three known resorcylic acid lactones, monocillin IV (1), monocillin II (5), and radicicol (6), were al more

• Advances, Interactions, and Future Developments in the CNS, Phenix, and Rosetta Structural Biology Software Systems

  Advances in our understanding of macromolecular structure come from experimental methods, such as X-ray crystallography, and also computational analysis of the growing number of atomic models obtained from such experiments. The later analyses have made it possible to develop powerful tools for struc more

• Insights into the structure and assembly of the Bacillus subtilis clamp-loader complex and its interaction with the replicative helicase

  The clamp-loader complex plays a crucial role in DNA replication by loading the β-clamp onto primed DNA to be used by the replicative polymerase. Relatively little is known about the stoichiometry, structure and assembly pathway of this complex, and how it interacts with the replicative helicase, i more

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