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4 Current white paper about the topic rna interference
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High-Throughput Cardiac Gene Expression Analysis Using the Universal ProbeLibrary and the Novel LightCycler® 1536 Real-Time PCR System
25-01-2010
Introduction Although congenital heart malformations are the most common birth defects in humans, the underlying pathomechanisms remain widely unknown. Through linkage analyzes and candidate-gene approaches, several gene mutations causing congenital heart defects (e.g., CITED2, GATA4, ...
HelpCorner - Gene Silencing
21-12-2009
FAQ: When was gene silencing first described? HelpCorner: In 2006, Andrew Z. Fire and Craig C. Mello received the Nobel Prize in Physiology and Medicine for their discovery of “RNA interference - gene silencing by double-stranded RNA”. “To their surprise, they found that double-stranded RNA ...
Dynamics of Kinases Involved in Cell Growth Using the xCELLigence System
08-06-2009
Introduction Studies investigating endogenous cellular regulatory mechanisms have substantially pushed the application of high-throughput screens. RNA interference has developed into an extremely powerful tool for mediating the loss-of-function of specific mRNA molecules and preventing their ...
qPCR Validation of Candidates for Modulators of the MAPkinase Signaling Pathway
19-05-2008
Introduction With the completion of the human genome sequence, the detailed understanding of gene functions by analyzing the structure, biological activities, and dynamics of the encoded proteins has become the next challenge. The technology of RNA interference (RNAi), which allows the ...
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