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4 Current white paper about the topic rna interferencerss
Introduction Although congenital heart malformations are the most common birth defects in humans, the underlying pathomechanisms remain widely unknown. Through linkage analyzes and candidate-gene approaches, several gene mutations causing congenital heart defects (e.g., CITED2, GATA4, ...
FAQ: When was gene silencing first described? HelpCorner: In 2006, Andrew Z. Fire and Craig C. Mello received the Nobel Prize in Physiology and Medicine for their discovery of “RNA interference - gene silencing by double-stranded RNA”. “To their surprise, they found that double-stranded RNA ...
Introduction Studies investigating endogenous cellular regulatory mechanisms have substantially pushed the application of high-throughput screens. RNA interference has developed into an extremely powerful tool for mediating the loss-of-function of specific mRNA molecules and preventing their ...
Introduction With the completion of the human genome sequence, the detailed understanding of gene functions by analyzing the structure, biological activities, and dynamics of the encoded proteins has become the next challenge. The technology of RNA interference (RNAi), which allows the ...