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3 Current white paper about the topic genetic mutations
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High-Throughput Cardiac Gene Expression Analysis Using the Universal ProbeLibrary and the Novel LightCycler® 1536 Real-Time PCR System
25-01-2010
Introduction Although congenital heart malformations are the most common birth defects in humans, the underlying pathomechanisms remain widely unknown. Through linkage analyzes and candidate-gene approaches, several gene mutations causing congenital heart defects (e.g., CITED2, GATA4, ...
Acquired Copy Number Alterations in Adult Acute Myeloid Leukemia Genomes
30-11-2009
Cytogenetic analysis of acute myeloid leukemia (AML) cells has accelerated the identification of genes important for AML pathogenesis. As shown in a recent scientific study, the use of an unbiased high-resolution genomic screen yields the identification of genes altered in AML genomes not ...
Experimental Workflow for Fast and Accurate Genotyping of Scrapie-resistant/sensitive Sheep
05-09-2007
IntroductionSeveral scientific studies support the claim that natural scrapie is associated with polymorphisms at three codons within the sheep prion protein (PrP) gene. Genotyping of these codons (codon 136 [alanine, valine], 154 [arginine, histidine], and 171 [glutamine, arginine, ...
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