Long high-resolution reads for medical genomics

07-02-2012

#img11503# Medicinal Genomics, a private company headquartered in Marblehead, Massachuetts, USA and the Netherlands, sequenced the entire genomes of Cannabis sativa and Cannabis indica, two strains of the therapeutic plant. These largest known Cannabis genome assemblies comprise over 131 ...

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14-10-2011

#img11015# SummeryBiomarkers are currently changing the way we diagnose and treat diseases. Today pharmacodynamic biomarkers are widely used in the industry elaborating optimal dosing of new drugs and predictive biomarkers have an enormous potential for companion diagnostics ...

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01-06-2011

Abstract The RealTime ready Configurator is a web-based configuration and ordering portal for function tested, custom RT-qPCR assays based on Universal ProbeLibrary (UPL) technology. It contains consolidated gene annotation information derived from three key public gene annotation resources ...

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01-06-2011

Abstract On the RealTime ready Configurator [1], we offer function tested human, mouse, and rat qPCR assays for gene expression quantification based on the unique Universal ProbeLibrary technology (UPL) [2]. The Universal ProbeLibrary is a set of short hydrolysis probes (8–9-mers) containing ...

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Prof. Marc Spehr on the New Understanding of Olfactory Neurosensorics

20-09-2010

#img6121# In his novel “Perfume – the Story of a Murderer”, Patrick Süskind managed to put the power of odors into words better than anyone before him. It may be a fascinating idea, but no one will ever be able to create the perfect fragrance that makes a person irresistibly attractive. In ...

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27-01-2010

The Nobel Assembly awarded this year’s Nobel Prize in Medicine to Elizabeth H. Blackburn, Jack W. Szostak, and Carol W. Greider for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase. With their ingenious genetic research and meticulous biochemical studies, ...

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25-01-2010

Introduction Although congenital heart malformations are the most common birth defects in humans, the underlying patho­mechanisms remain widely unknown. Through linkage analyzes and candidate-gene approaches, several gene mutations causing congenital heart defects (e.g., CITED2, GATA4, ...

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04-01-2010

Pyrosequencing of complementary DNA-PCR ampli­cons was used to determine comprehensive major histocompatibility complex (MHC) class-I genotypes in primates that provide essential preclinical models for studies of infectious disease, vaccine development, and transplantation. By sequence-based ...

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21-12-2009

FAQ: When was gene silencing first described? HelpCorner: In 2006, Andrew Z. Fire and Craig C. Mello received the Nobel Prize in Physiology and Medicine for their discovery of “RNA interference - gene silencing by double-stranded RNA”. “To their surprise, they found that double-stranded RNA ...

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21-12-2009

Introduction High Resolution Melting (HRM) is a novel and promising screening technique used for mutation analysis and detection. Its application prevents the need to sequence all the exons of a gene when looking for novel mutations. The method is therefore time- and cost-effective for the ...

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