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53 Current white paper about the topic genes

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Cannabis genome sequenced with 454 GS FLX+ System

Long high-resolution reads for medical genomics

07-Feb-2012

Medicinal Genomics sequenced the entire genomes of Cannabis sativa and Cannabis indica, two strains of the therapeutic plant. These largest known Cannabis genome assemblies comprise over 131 billion bases of sequence and will advance research on the

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Clinical Biomarkers: Novel Tools for Pharmacodynamic Applications

14-Oct-2011

Biomarkers are currently changing the way we diagnose and treat diseases. Today pharmacodynamic biomarkers are widely used in the industry elaborating optimal dosing of new drugs and predictive biomarkers have an enormous potential for companion diag

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RealTime ready RT-qPCR Assay Development and Qualification

01-Jun-2011

On the RealTime ready Configurator, we offer function tested human, mouse, and rat qPCR assays for gene expression quantification based on the unique Universal ProbeLibrary technology (UPL). The Universal ProbeLibrary is a set of short hydrolysis pro

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RealTime ready qPCR Assay Design and Configuration Portal Content

01-Jun-2011

The gene and transcript annotational content of the RealTime ready Configurator offers a combined view of three of the main gene annotation authorities. The positional information of the lab-tested RealTime ready assays regarding transcript or exon c

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Sniffing Out the Secrets of Social Behavior

Prof. Marc Spehr on the New Understanding of Olfactory Neurosensorics

20-Sep-2010

In his novel "Perfume - the Story of a Murderer", Patrick Süskind managed to put the power of odors into words better than anyone before him. It may be a fascinating idea, but no one will ever be able to create the perfect fragrance that makes a pers

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Nobel Prize for Solving the End-Replication Problem

27-Jan-2010

The Nobel Assembly awarded this year's Nobel Prize in Medicine to Elizabeth H. Blackburn, Jack W. Szostak, and Carol W. Greider for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase. With their ingenious genetic re

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High-Throughput Cardiac Gene Expression Analysis Using the Universal ProbeLibrary and the Novel LightCycler® 1536 Real-Time PCR System

25-Jan-2010

Although congenital heart malformations are the most common birth defects in humans, the underlying patho­mechanisms remain widely unknown. Through linkage analyzes and candidate-gene approaches, several gene mutations causing congenital heart defect

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Mutation Scanning Using High Resolution Melting or dHPLC: a Performance Comparison Study

21-Dec-2009

High Resolution Melting (HRM) is a novel and promising screening technique used for mutation analysis and detection. Its application prevents the need to sequence all the exons of a gene when looking for novel mutations. The method is therefore time-

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Altered Expression of Broad Range of Protease Genes in SH-SY5Y Neuroblastoma Cells after Bortezomib Exposure

14-Dec-2009

Neuroblastoma cell lines can be models for the responsiveness of neuroblastomas to chemotherapy-induced cell death as well as for the sensitivity of untransformed neuro-nal cells to toxic side-effects of chemotherapy. Both phenom-ena are relevant to

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Acquired Copy Number Alterations in Adult Acute Myeloid Leukemia Genomes

30-Nov-2009

To complement cytogenetic studies and to identify genes altered in AML genomes, Walter and co-workers performed a genome-wide copy number analysis with paired normal and tumor DNA obtained from 86 adult subjects with de novo AML using 1.85 million fe

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